Michele Fiore

Research staff

Degree in biology (2006), Clinical Pathology graduate school (2014)

Contact:

- Email michele.fiore@ibf.cnr.it
- Phone +39-010-6475555
- Location Genova

Research interests:

- Molecular pharmacology of cystic fibrosis
- Functional and structural studies of human CLC protein complexes involved in genetic diseases
- Neurotoxic effect of per- and polyfluoroalkyl substances (PFAS)

Key publications:

Elsa Hernando, Valeria Capurro, Claudia Cossu, Michele Fiore, María García-Valverde, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás, Oscar Moran, Olga Zegarra-Moran, Roberto Quesada Small molecule anionophores promote transmembrane anion permeation matching CFTR activity Scientific Reports volume 8, Article number: 2608 (2018)

Rebeca Vindas?Smith, Michele Fiore, Melissa Vásquez, Patricia Cuenca, Gerardo Del Valle, Laura Lagostena, Héctor Gaitán?Peñas, Raúl Estevez, Michael Pusch, Fernando Morales Identification and Functional Characterization of CLCN1 Mutations Found in Nondystrophic Myotonia Patients Hum Mutat. 2016 Jan;37(1).

Claudia Cossu, Michele Fiore, Debora Baroni, Valeria Capurro, Emanuela Caci, Maria Garcia-Valverde, Roberto Quesada, Oscar Moran Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy Front. Pharmacol., 07 August 2018

Michele Fiore, Claudia Cossu, Valeria Capurro, Cristiana Picco, Alessandra Ludovico, Marcin Mielczarek, Israel Carreira?Barral, Emanuela Caci, Debora Baroni, Roberto Quesada, Oscar Moran Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis Br. J. Pharmacol. 2019, 176, 1764–1779.

Ambra Gianotti, Valeria Capurro, Livia Delpiano, Marcin Mielczarek, María García-Valverde, Israel Carreira-Barral, Alessandra Ludovico, Michele Fiore, Debora Baroni, Oscar Moran, Roberto Quesada, Emanuela Caci Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia nt. J. Mol. Sci. 2020, 21(4), 1488

Publications (17):

Reduced Serum Brain-Derived Neurotrophic Factor in Infants Affected by Severe Bronchiolitis
Nenna, R.; Petrella, C.; Bonci, E.; Papoff, P.; Di Jorgi, M.; Petrarca, L.; Conti, M. G.; Barbato, C.; Pietrangeli, A.; Fiore, M.; Midulla, F.; Antonelli, G.; Matera, L.; Bonci, F.; Conti, M.; Di Mattia, G.; Frassanito, A.; Mancino, E.
CURRENT NEUROPHARMACOLOGY, 22, 2024
DOI: 10.2174/1570159X22999240223153901

Correctors modify the bicarbonate permeability of F508del-CFTR
Fiore, Michele; Picco, Cristiana; Moran, Oscar
Scientific Reports, 10, 2020
DOI: 10.1038/s41598-020-65287-4

Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
Gianotti, Ambra; Capurro, Valeria; Delpiano, Livia; Mielczarek, Marcin; Garcia-Valverde, Maria; Carreira-Barral, Israel; Ludovico, Alessandra; Fiore, Michele; Baroni, Debora; Moran, Oscar; Quesada, Roberto; Caci, Emanuela
International Journal Of Molecular Sciences, 21, 2020
DOI: 10.3390/ijms21041488

The different anion transport capability of prodiginine- and tambjamine-like molecules
Michele Fiore, María García-Valverde, Israel Carreira-Barral, Oscar Moran
European Journal of Pharmacology, 889, 2020
DOI: 10.1016/j.ejphar.2020.173592

Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
Fiore M, Cossu C, Capurro V, Picco C, Ludovico A, Mielczarek M, Carreira-Barral I, Caci E, Baroni D, Quesada R, Moran O
British journal of pharmacology, 176, 2019
DOI: 10.1111/bph.14649

Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: A candidate for cystic fibrosis therapy
Cossu C, Fiore M, Baroni D, Capurro V, Caci E, Garcia-Valverde M, Quesada R, Moran O
Frontiers in Pharmacology, 9, 2018
DOI: 10.3389/fphar.2018.00852

Small molecule anionophores promote transmembrane anion permeation matching CFTR activity
Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R
Scientific reports , 8, 2018
DOI: 10.1038/s41598-018-20708-3

Identification and Functional Characterization of CLCN1 Mutations Found in Nondystrophic Myotonia Patients
Vindas-Smith R.; Fiore M.; Vasquez M.; Cuenca P.; del Valle G.; Lagostena L.; Gaitan-Penas H.; Estevez R.; Pusch M.; Morales F.
Human mutation, 37, 2016
DOI: 10.1002/humu.22916

The biophysics of piezo1 and piezo2 mechanosensitive channels
Soattin L.; Fiore M.; Gavazzo P.; Viti F.; Facci P.; Raiteri R.; Difato F.; Pusch M.; Vassalli M.
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.06.013

Fighting in the aged male mouse increases the expression of TrkA and TrkB in the subventricular zone and in the hippocampus.
Fiore, M; Amendola, T; Triaca, V; Alleva, E; Aloe, L
BEHAVIOURAL BRAIN RESEARCH, 157/2, 2005

Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells' activation
Fiore M; Amendola T; Triaca V; Tirassa P; Alleva E; Aloe L
EUROPEAN JOURNAL OF NEUROSCIENCE, 17, 2003

EGF and NGF injected into the brain of old mice enhance BDNF and ChAT in proliferating subventricular zone
Tirassa, P; Triaca, V; Amendola, T; Fiore, M; Aloe, L
JOURNAL OF NEUROSCIENCE RESEARCH, 72, 2003

Postnatal changes in nerve growth factor and brain derived neurotrophic factor levels in the retina, visual cortex, and geniculate nucleus in rats with retinitis pigmentosa.
Amendola, T; Fiore, M; Aloe, L
NEUROSCIENCE LETTERS, 345, 2003

Brain NGF and EGF administration improves passive avoidance response and stimulates brain precursor cells in aged male mice.
Fiore, M; Triaca, V; Amendola, T; Tirassa, P; Aloe, L
PHYSIOLOGY & BEHAVIOR, 77, 2002

Short-term hypergravity influences NGF and BDNF expression, and mast cell distribution in the lungs and heart of adult male mice.
Antonelli, A; Santucci, D; Amendola, T; Triaca, V; Corazzi, G; Francia, N; Fiore, M; Alleva, E; Aloe, L
JOURNAL OF GRAVITATIONAL PHYSIOLOGY, 9, 2002

Bromodeoxyuridine and methylazoxymethanol exposure during brain development affects behavior in rats: consideration for a role of nerve growth factor and brain derived neurotrophic factor.
Fiore M.; Aloe L.; Westenbroek C.; Amendola T.; Antonelli A.; Korf J.
NEUROSCIENCE LETTERS, 309/2, 2001

Effect of hypergravity on the mouse basal expression of NGF and BDNF in the retina, visual cortex and geniculate nucleus: correlative aspects with NPY immunoreactivity.
Aloe, L; Fiore, M; Santucci, D; Amendola, T; Antonelli, A; Francia, N; Corazzi, G; Alleva, E
NEUROSCIENCE LETTERS, 302/1, 2001