Neurotoxic effect of per- and polyfluoroalkyl substances (PFAS)

In collaboration with Professor Francesco Dondero from the Department of Sciences and Technological Innovation (DISIT) at the University of Eastern Piemonte, coordinator for the European project "H2020-EU.3.5. SCENARIOS," I am currently conducting a study on the interaction of per- and polyfluoroalkyl substances (PFAS) at the level of neuronal circuits, focusing particularly on their interaction with neurotransmitters.
These substances, commonly known as 'forever chemicals,' have recently garnered media attention due to their highly polluting nature as compounds that are widespread and persistent in the environment. PFAS constitute a family of chemical compounds extensively used by industries for their water and oil repellency, as well as their resistance to natural degradation processes, posing a serious risk to human health and the environment. They can accumulate in surface and groundwater, entering the food chain through plants and accumulating in the blood of animals and humans, with health consequences that are still the subject of numerous scientific studies. Recent research has highlighted alterations in the liver, thyroid, immune and reproductive systems, while neurologically, they are associated with increased incidences of dementia, Alzheimer's disease, autism, attention deficit, and hyperactivity.
Experimental studies conducted by Professor Dondero's group suggest a neurotoxic effect of these substances. To understand the potential interaction between these substances and neurotransmitter receptors, we are investigating their targeted action on channel receptors through whole-cell patch-clamp recordings on human neuroblastoma cell lines used as a model. Considering their impact on neurotransmitters, future developments may involve an in-depth study of synaptic transmission and plasticity, both on brain slices and organoids, to characterize the effects of these substances on neuronal networks and highlight potential consequences on cognitive abilities.

Members:
Michele Fiore
Alessandra Picollo