Fabio Librizzi
Research staff
Since December 2011: Researcher at IBF.
2008-2011: Teacher of Mathematics and Physics at High School.
2004-2008: Post-Doc, Department of Physics, University of Palermo.
2002-2003: Post-Doc, Niels Bohr Institute, University of Copenhagen.
2001: PhD in physics.
1998: Laurea in Physics, University of Palermo, cum laude.
orcid://0000-0003-4900-382X,
Contact:
- Email fabio.librizzi@ibf.cnr.it
- Phone +39-091-6809317
- Location Palermo
Research interests:
- Dynamical properties of proteins (Principal investigator)
- Amyloid aggregation processes and their inhibition
- Model Membrane Systems and Interaction Studies
- Liposome as drug delivery system
- Characterisation of extracellular vescicles
Further collaborations:
- Antonio Cupane (Università degli studi di Palermo)
- Maria Grazia Ortore (Università delle Marche)
- Judith Peters (ILL, Grenoble)
- Valeria Vetri (Università degli studi di Palermo)
Financial support:
- Percorsi formative nei settori Biotecnologia, Biomedicina e Agroalimentare. Progetto FSE 2014/2020
Key publications:
Librizzi F, Caliò A, Cupane A (2018) Dynamical properties of myoglobin in an ultraviscous water-glycerol solvent investigated with elastic neutron scattering and FTIR spectroscopy. J. Mol. Liq. 268: 242-248. doi: 10.1016/j.molliq.2018.07.050
Librizzi F, Carrotta R, Peters J, Cupane A (2018) The effects of pressure on the energy landscape of proteins. Sci. Rep. 8: 2037. doi: 10.1038/s41598-018-20417-x
Librizzi F, Carrotta R, Spigolon D, Bulone D, San Biagio PL (2014) alfa-casein inhibits insulin amyloid formation by preventing the onset of secondary nucleation processes. J. Phys. Chem. Lett. 5: 3043-3048. doi: 10.1021/jz501570m
Foderà V, Librizzi F, Gronning M, van de Weert M, Leone M (2008) Secondary nucleation and accessible surface in insulin amyloid fibril formation. J. Phys. Chem. B. 112: 3853-3858. doi: 10.1021/jp710131u
Librizzi F, Rischel C (2005) The kinetic behavior of insulin fibrillation is determined by heterogeneous nucleation pathways. Protein Sci. 14: 3129-3134. doi: 10.1110/ps.051692305
Publications (27):
Moringa oleifera Extracts as Strategic Phyto‐Therapy for Alzheimer's DiseaseCarrotta, Rita; Vilasi, Silvia; Costa, Maria Assunta; Librizzi, Fabio; Martorana, Vincenzo; Passantino, Rosa; Buzzanca, Carla; di Stefano, Vita; Ortore, Maria Grazia; Piccirillo, Silvia; Preziuso, Alessandra; Magi, Simona; Mangione, Maria Rosalia
FOOD SCIENCE & NUTRITION, 13, 2025
DOI: 10.1002/fsn3.70007
alphaS1-Casein administration to a C. elegans model of Alzheimer's disease through proteoliposome delivery
Carrotta, Rita; Paterna, Angela; Santonicola, Pamela; DI PRIMA, Giulia; Rao, Estella; Raccosta, Samuele; Zampi, Giuseppina; Oscar, Moran; Manno, Mauro; DI SCHIAVI, Elia; Librizzi, Fabio
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 52, 2023
Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs
Vitale, Paola; Librizzi, Fabio; Vaiana Andrea, C.; Capuana, Elisa; Pezzoli, Maurizio; Shi, Ying; Romani, Armando; Migliore, Michele; Migliore, Rosanna
FRONTIERS IN CELLULAR NEUROSCIENCE, 2023
αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease
Paterna, A.; Santonicola, P.; Di Prima, G.; Rao, E.; Raccosta, S.; Zampi, G.; Russo, C.; Moran, O.; Manno, M.; Di Schiavi, E.; Librizzi, F.; Carrotta, R.
ACS CHEMICAL NEUROSCIENCE, 14, 2023
DOI: 10.1021/acschemneuro.3c00239
Small Angle X-ray Scattering Sensing Membrane Composition: The Role of Sphingolipids in Membrane-Amyloid beta-Peptide Interaction
Carrotta, Rita; Mangione, Maria Rosalia; Librizzi, Fabio; Moran, Oscar
biology (basel), 11, 2022
DOI: 10.3390/biology11010026
The Possible Role of the Type I Chaperonins in Human Insulin Self-Association
Pizzo, Federica; Mangione, MARIA ROSALIA; Librizzi, Fabio; Manno, Mauro; Martorana, Vincenzo; Noto, Rosina; Vilasi, Silvia
LIFE, 12, 2022
DOI: 10.3390/life12030448
Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto, Sabrina; Barone, Maria E.; Fierli, David; Aranyos, Anita; Adamo, Giorgia; Bo?i?, Darja; Romancino, Daniele P.; Stanly, Christopher; Parkes, Rachel; Morsbach, Svenja; Raccosta, Samuele; Paganini, Carolina; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Capasso Palmiero, Umberto; Santonicola, Pamela; Igli?, Ales; Gai, Meiyu; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Landfester, Katharina; Liguori, Giovanna L.; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Manno, Mauro; Touzet, Nicolas; Bongiovanni, Antonella
biomaterials science (print)issn: 2047-4830royal society of chemistry, 9, 2021
DOI: 10.1039/d0bm01696a
Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo, Giorgia; Fierli, David; Romancino, Daniele P.; Picciotto, Sabrina; Barone, Maria E.; Aranyos, Anita; Bo?i?, Darja; Morsbach, Svenja; Raccosta, Samuele; Stanly, Christopher; Paganini, Carolina; Gai, Meiyu; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Randazzo, Loredana; Parkes, Rachel; Capasso Palmiero, Umberto; Rao, Estella; Paterna, Angela; Santonicola, Pamela; Igli?, Ales; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Liguori, Giovanna L.; Landfester, Katharina; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Touzet, Nicolas; Manno, Mauro; Bongiovanni, Antonella
journal of extracellular vesiclesissn: 2001-3078järfälla : co-action pub., 10, 2021
DOI: 10.1002/jev2.12081
Scaling concepts in serpin polymer physics
Raccosta S.; Librizzi F.; Jagger A.M.; Noto R.; Martorana V.; Lomas D.A.; Irving J.A.; Manno M.
materials (basel)issn: 1996-1944molecular diversity preservation international, 14, 2021
DOI: 10.3390/ma14102577
Valorization of apple peels through the study of the effects on the amyloid aggregation process of ?-casein
Guarrasi V., Rappa G.C., Costa M.A., Librizzi F., Raimondo M., Di Stefano V., Germanà M.A., Vilasi S.
molecules (basel, online)issn: 1420-3049molecules/mdpi, molecular diversity preservation international, 26, 2021
DOI: 10.3390/molecules26082371
Light scattering as an easy tool to measure vesicles weight concentration
Di Prima, G., Librizzi, F., Carrotta, R.
membranes, 10, 2020
DOI: 10.3390/membranes10090222
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
Journal of physical chemistry b, 123, 2019
DOI: 10.1021/acs.jpcb.8b11719
Blue autofluorescence in protein aggregates "lighted on" by UV induced oxidation
Fricano A, Librizzi F, Rao E, Alfano C, Vetri V
Biochimica et biophysica acta. Proteins and proteomics, 1867, 2019
DOI: 10.1016/j.bbapap.2019.07.011
Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 10, 2019
DOI: 10.1021/acschemneuro.9b00183
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces, 170, 2018
DOI: 10.1016/j.colsurfb.2018.06.032
Dynamical properties of myoglobin in an ultraviscous water-glycerol solvent investigated with elastic neutron scattering and FTIR spectroscopy
Librizzi F, Caliò A, Cupane A
Journal of molecular liquids, 268, 2018
DOI: 10.1016/j.molliq.2018.07.050
The effects of pressure on the energy landscape of proteins
Librizzi F, Carrotta R, Peters J, Cupane A
Scientific reports , 8, 2018
DOI: 10.1038/s41598-018-20417-x
Investigation Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.07.008
Amyloid ?-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.010
Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Aging , 8, 2016
DOI: 10.18632/aging.101004
Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects, 1860, 2016
DOI: 10.1016/j.bbagen.2016.07.019
Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.006
alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes
Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi
Journal of physical chemistry letters, 5, 2014
DOI: 10.1021/jz501570m
Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Dav
PloS one, 9, 2014
DOI: 10.1371/journal.pone.0097657
alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
Journal of physical chemistry b, 116, 2012
DOI: 10.1021/jp307417x
Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection.
Foderà, V., M. Groenning, V. Vetri, F. Librizzi, S. Spagnolo, C. Cornett, L. Oltzen, M. Van de Weert, and M. Leone.
Journal of physical chemistry b, 112, 2008
Amyloid fibrils formation and amorphous aggregation in concanavalin A.
Vetri V; Canale C; Relini A; Librizzi F; Militello V; Gliozzi A; Leone M.
BIOPHYSICAL CHEMISTRY, 125, 2007
DOI: 10.1016/j.bpc.2006.07.012