Maria Rosalia Mangione
Research staff
From 2008 Technologist at IBF - Palermo
2006 Research Project for “realizzazione di un centro regionale per il controllo di qualità di oli vergini d' oliva”.
2004 PhD on “Technologies of biologically active substances” Faculty of Pharmacia – Palermo
1999 Degree cum laude on " Pharmaceutical Chemistry and Technology”
orcid://0000-0002-3466-2569,
Contact:
- Email mariarosalia.mangione@ibf.cnr.it
- Phone +39-091-6809334
- Location Palermo
Research interests:
- Amyloid aggregation processes and their inhibition (Principal investigator)
- Extraction, identification and characterization of naturally occurring compounds and study of their biological activity on cell lines.
- Model Membrane Systems and Interaction Studies
- Liposome as drug delivery system
- Production, Purification, Mutagenesis and Characterization of proteins expressed in E. coli
Financial support:
- Progetto FSE 2014/2020 “Percorsi formative nei settori Biotecnologia, Biomedicina e Agroalimentare”.
- Progetto istituzionale CNR/IBF SIVA “Caratterizzazione del fattore Heat Shock Factor 1 (HSF1) e suoi complessi molecolari”.
- Progetto istituzionale CNR/IBF “Stabilità e funzione di proteine”.
Key publications:
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R (2018) Biophysical characterization of asolectin-squalene liposomes. Colloids and Surface B: Biointerfaces 170:479-487
Mangione MR, Vilasi S, Marino C, et al. (2016) Hsp60, amateur chaperone in amyloid-beta fibrillogenesis. Biochimica et Biophysica Acta (BBA)-General Subjects 1860(11):2474-2483
Mangione MR, Palumbo Piccionello A, Marino C, et al. (2015) Photo-inhibition of Abeta fibrillation mediated by a newly designed fluorinated oxadiazole. RSC Advances 5(21):16540-16548
Guarrasi V, Mangione MR, Sanfratello V, et al. (2011) Quantification of underivatized fatty acids from vegetable oils by HPLC with UV detection. Journal of Chromatography Science 48(8):663-668
Mangione MR, Giacomazza D, Bulone D, et al. (2003) Thermoreversible gelation of K-Carrageenan: relation between conformational transition and aggregation. Biophysical Chemistry 104(1):95-105
Publications (26):
Moringa oleifera Extracts as Strategic Phyto‐Therapy for Alzheimer's DiseaseCarrotta, Rita; Vilasi, Silvia; Costa, Maria Assunta; Librizzi, Fabio; Martorana, Vincenzo; Passantino, Rosa; Buzzanca, Carla; di Stefano, Vita; Ortore, Maria Grazia; Piccirillo, Silvia; Preziuso, Alessandra; Magi, Simona; Mangione, Maria Rosalia
FOOD SCIENCE & NUTRITION, 13, 2025
DOI: 10.1002/fsn3.70007
Small Angle X-ray Scattering Sensing Membrane Composition: The Role of Sphingolipids in Membrane-Amyloid beta-Peptide Interaction
Carrotta, Rita; Mangione, Maria Rosalia; Librizzi, Fabio; Moran, Oscar
biology (basel), 11, 2022
DOI: 10.3390/biology11010026
The Possible Role of the Type I Chaperonins in Human Insulin Self-Association
Pizzo, Federica; Mangione, MARIA ROSALIA; Librizzi, Fabio; Manno, Mauro; Martorana, Vincenzo; Noto, Rosina; Vilasi, Silvia
LIFE, 12, 2022
DOI: 10.3390/life12030448
Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
Journal of physical chemistry b, 123, 2019
DOI: 10.1021/acs.jpcb.8b11719
Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 10, 2019
DOI: 10.1021/acschemneuro.9b00183
Biochemical and biophysical characterization of water-soluble pectin from Opuntia ficus-indica and its potential cytotoxic activity
Lefsih K, Giacomazza D, Passantino R, Costa MA, Bulone D, Mangione MR, Guarrasi V, Mingoia F, San Biagio PL, Madani K
Phytochemistry, 154, 2018
DOI: 10.1016/j.phytochem.2018.06.015
Biophysical characterization of asolectin-squalene liposomes
Costa MA, Mangione MR, Santonocito R, Passantino R, Giacomazza D, Librizzi F, Moran O, Carrotta R
Colloids and surfaces. B, Biointerfaces, 170, 2018
DOI: 10.1016/j.colsurfb.2018.06.032
The precious content of the olive mill wastewater: The protective effects of the antioxidant fraction in cell cultures
Giacomazza D, D'Andrea D, Provenzano A, Picone P, Provenzano F, Guarrasi V, Raimondo M, San Biagio PL, Passantino R, Mangione MR, Di Carlo M, Costa MA
CyTA: journal of food, 16, 2018
DOI: 10.1080/19476337.2018.1458752
Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection
Presti G, Guarrasi V, Gulotta E, Provenzano F, Provenzano A, Giuliano S, Monfreda M, Mangione MR, Passantino R, San Biagio PL, Costa MA, Giacomazza D
Biophysical chemistry , 230, 2017
DOI: 10.1016/j.bpc.2017.09.002
Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti A, Palumbo Piccionello A, Sgarbossa A, Vilasi S, Ricci C, Ghetti F, Spinozzi F, Marino Gammazza A, Giacalone V, Martorana A, Lauria A, Ferrero C, Bulone D, Mangione MR, San Biagio PL, Ortore MG
RSC advances, 7, 2017
DOI: 10.1039/c7ra05300b
Investigation Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.07.008
Pectin from Opuntia ficus indica: Optimization of microwave-assisted extraction and preliminary characterization
Lefsih K, Giacomazza D, Dahmoune F, Mangione MR, Bulone D, San Biagio PL, Passantino R, Costa MA, Guarrasi V, Madani K
Food chemistry, 221, 2017
DOI: 10.1016/j.foodchem.2016.10.073
Simultaneous Determination of Caffeine and Chlorogenic Acids in Green Coffee by UV/Vis Spectroscopy
Navarra G, Moschetti M, Guarrasi V, Mangione MR, Militello V, Leone M
Journal of Chemistry, 2017
DOI: 10.1155/2017/6435086
Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects, 1860, 2016
DOI: 10.1016/j.bbagen.2016.07.019
On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions
Dispenza C, Sabatino MA, Grimaldi N, Mangione MR, Walo M, Murugan E, Jonsson M
RSC advances, 6, 2016
DOI: 10.1039/c5ra23926e
Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.006
Temporal control of xyloglucan self-assembly into layered structures by radiation-induced degradation
Todaro S, Sabatino MA, Mangione MR, Picone P, Di Giacinto ML, Bulone D, Dispenza C
Carbohydrate polymers, 152, 2016
DOI: 10.1016/j.carbpol.2016.07.005
Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics
Noto, Rosina; Santangelo, Maria Grazia; Levantino, Matteo; Cupane, Antonio; Mangione, Maria Rosalia; Parisi, Daniele; Ricagno, Stéfano; Bolognesi, Martino; Manno, Mauro; Martorana, Vincenzo
Biochimica et biophysica acta. Proteins and proteomics , 1854, 2015
DOI: 10.1016/j.bbapap.2014.10.002
Photo-inhibition of A beta fibrillation mediated by a newly designed fluorinated oxadiazole
Mangione, M. R.; Piccionello, A. Palumbo; Marino, C.; Ortore, M. G.; Picone, P.; Vilasi, S.; Di Carlo, M.; Buscemi, S.; Bulone, D.; Biagio, P. L. San
RSC advances , 5, 2015
DOI: 10.1039/c4ra13556c
Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Dav
PloS one, 9, 2014
DOI: 10.1371/journal.pone.0097657
Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans
Todaro, S.; Sabatino, M. A.; Walo, M.; Mangione, M. R.; Bulone, D.; Dispenza, C.
Radiation physics and chemistry , 94, 2014
DOI: 10.1016/j.radphyschem.2013.05.055
Entrapment of A Beta 1-40 peptide in unstructured aggregates
Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL
Journal of physics. Condensed matter, 24, 2012
DOI: 10.1088/0953-8984/24/24/244103
On the molecular structure of human neuroserpin polymers
Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M
Proteins, 80, 2012
Quantification of underivatized fatty acids from vegetable oils by HPLC-UV
Guarrasi V, Mangione MR, Sanfratello V, Martorana V, Bulone D
Journal of chromatographic science, 48, 2010
Synergistic interaction of Locust Bean Gum and Xanthan investigated by rheology and light scattering
Sandolo C, Bulone D, Mangione MR, Margheritelli S, Di Meo C, Alhaique F, Matricardi P, Coviello T
Carbohydrate polymers, 82, 2010
Relation between structural and release properties in a polysaccharide gel system.
Mangione M. R.; D. Giacomazza; G. Cavallaro; D. Bulone (1); V. Martorana; P. L. San Biagio (1).
Biophysical chemistry, 129, 2007
DOI: 10.1016/j.bpc.2007.04.013