Pier Luigi San Biagio

Pier Luigi San Biagio has coordinated the research activity in the field of Biophysics at the CNR-IAIF since its creation in 1980. After more than one year spent working at NIH (Bethesda, MD, USA), he returned in Italy and set up a lab with outstanding equipment for the characterization of biomolecular aggregation. He was Director of the IAIF from 1998 to 2002 when the Institute became part of the Biophysics Institute as Palermo U.O.S.. Since then, he has been in charge of U.O.S. (2002-2015) and director of the research group “Processi di Aggregazione Biomolecolare”. Its research activity is based on complementary approaches to the study of biomolecular aggregation at microscopic and mesoscopic level.

orcid://0000-0002-4622-7361,

Research interests:

- Biomolecular Aggregation Processes (Principal investigator)
- Protein aggregation and the onset of neurodegenerative diseases (Principal investigator)
- Structure and Functionality of Molecular chaperones
- Polysaccharides Substitutes for Gluten-Free Baking
- Insulin drug delivery in neurodegeneration
- Study of natural and chemically modified natural polymers for biotechnological applications
- Development of bio-adhesives for wet environments from marine mussels
- Laboratory of protein engineering for production of recombinant proteins.
- Extraction and characterization of polyphenols from complex systems of agri-food origin; study of antioxidant properties and of neuroprotective and anti-amyloidogenic effects in neurodegenerative processes

Further collaborations:

- F. Cappello (Università di Palermo, BIONEC e IEMEST)
- A. Padova (Fondazione Ri.MED)
- A. Pastore (Dip. Medicina Molecolare, Università di Pavia )
- M. Leone (Dipartimento di Fisica e Chimica, Università di Palermo)

Financial support:

- Avviso 11/2017 Rafforzare l'occupabilità nel sistema R&S e la nascita di spin off di ricerca in Sicilia – P.O. FSE 2014/2020

Key publications:

P. Picone, G. Porcelli, C. Caruso Bavisotto, D. Nuzzo, G. Galizzi, P. L. San Biagio, D. Bulone, M. Di Carlo, Synaptosomes: new vesicles for neuronal mitochondrial transplantation, . J Nanobiotechnol. (2021)

L. A. Ditta, D. Bulone, P. L. San Biagio, R. Marino, D. Giacomazza, R. Lapasin, The degree of compactness of the incipient High Methoxyl Pectin networks. A rheological insight at the sol-gel transition. Intl. J. Biol. Macromol. 158 (2020) 985–993.

R. Santonocito et al., Recombinant mussel protein Pvfp-5beta: a potential tissue bioadhesive. J Biol Chem 294 (2019) 12826 – 12835.

D. Bulone, P.L. San Biagio, T. Quinones-Ruix, M.R. Alomar, I.K. Lednev, F.T. Robb, E. Conway de Macario, A.J. Macario, A multipronged method for assessing the effects of mutations on chaperone molecules causing human chaperonopathies, in: C.M. Gomes (Ed.) Protein Misfolding Diseases: Methods and Protocols, Springer (2019) pp. 69-92.

S. Vilasi, D. Bulone, C. Caruso Bavisotto, C. Campanella, A.M. Gammazza, P.L. San Biagio, F. Cappello, E. Conway de Macario, A.J. Macario, Chaperonin of Group I: Oligomeric spectrum and biochemical-biological implications, Frontiers in Molecular Biosciences, 4 (2018) 1 - 14.

Publications (65):

Oligomeric State and Holding Activity of Hsp60
Caruso Bavisotto, C; Provenzano, A; Passantino, R; Marino Gammazza, A; Cappello, F; SAN BIAGIO, PIER LUIGI; Bulone, D
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 2023
DOI: 10.3390/ijms24097847

From Small Peptides to Large Proteins against Alzheimer'sDisease.
Picone, Pasquale; Sanfilippo, Tiziana; Vasto, Sonya; Baldassano, Sara; Guggino, Rossella; Nuzzo, Domenico; Bulone, Donatella; SAN BIAGIO, PIER LUIGI; Muscolino, Emanuela; Monastero, Roberto; Dispenza, Clelia; Giacomazza, Daniela
BIOMOLECULES, 12(10), 2022
DOI: 10.3390/biom12101344

Neurological Consequences, Mental Health, Physical Care, and Appropriate Nutrition in Long-COVID-19
Picone P.; Sanfilippo T.; Guggino R.; Scalisi L.; Monastero R.; Baschi R.; Mandala V.; San Biagio P.L.; Rizzo M.; Giacomazza D.; Dispenza C.; Nuzzo D.
cellular and molecular neurobiology, 2022
DOI: 10.1007/s10571-022-01281-w

Recombinant mussel protein Pvfp5? enhances cell adhesion of poly(vinyl alcohol)/k-carrageenan hydrogel scaffolds
Muscolino, Emanuela and Costa, Maria Assunta and Sabatino, Maria Antonietta and Alessi, Sabina and Bulone, Donatella and Biagio, Pier Luigi San and Passantino, Rosa and Giacomazza, Daniela and Dispenza, Clelia
international journal of biological macromolecules, 211, 2022
DOI: 10.1016/j.ijbiomac.2022.05.068

Recovery from Food Waste-Biscuit Doughs Enriched with Pomegranate Peel Powder as a Model of Fortified Aliment
Nuzzo Domenico; Picone Pasquale; Lozano Sanchez Jesus; Borras-Linares Isabel; Guiducci Alessandro; Muscolino Emanuela; Giacomazza Daniela; Sanfilippo Tiziana; Guggino Rossella; Bulone Donatella; Dispenza Clelia; San Biagio Pier Luigi; Lapasin Romano
biology (basel), 11, 2022
DOI: 10.3390/biology11030416

Synaptosomes: new vesicles for neuronal mitochondrial transplantation
Picone Pasquale; Porcelli Gaetana; Bavisotto Celeste Caruso; Nuzzo Domenico; Galizzi Giacoma; San Biagio Pier Luigi; Bulone Donatella; Di Carlo Marta;
journal of nanobiotechnologyissn: 1477-3155biomed central,, 19, 2021
DOI: 10.1186/s12951-020-00748-6

Agarose/κ-carrageenan-based hydrogel film enriched with natural plant extracts for the treatment of cutaneous wounds
Ditta, L.A., Rao, E., Provenzano, F., Sánchez, J.L., Santonocito, R., Passantino, R., Costa, M.A., Sabatino, M.A., Dispenza, C., Giacomazza, D., San Biagio, P.L., Lapasin, R.
International Journal of Biological Macromolecules, 164, 2020
DOI: 10.1016/j.ijbiomac.2020.08.170

Multi-scale structural analysis of xyloglucan colloidal dispersions and hydro-alcoholic gels
Dispenza, Clelia; Todaro, Simona; Sabatino, Maria Antonietta; Martino, Delia; Martorana, Vincenzo; San Biagio, Pier Luigi; Maffei, Paola; Bulone, Donatella
Cellulose, 27, 2020
DOI: 10.1007/s10570-020-03004-0

The degree of compactness of the incipient High Methoxyl Pectin networks. A rheological insight at the sol-gel transition
Ditta, Lorena Anna; Bulone, Donatella; San Biagio, Pier Luigi; Marino, Rosamaria; Giacomazza, Daniela; Lapasin, Romano
International Journal Of Biological Macromolecules, 158, 2020
DOI: 10.1016/j.ijbiomac.2020.05.019

Amyloid jams: Mechanical and dynamical properties of an amyloid fibrillar network
Martorana V, Raccosta S, Giacomazza D, Ditta LA, Noto R, Biagio PLS, Manno M
Biophysical chemistry, 253, 2019
DOI: 10.1016/j.bpc.2019.106231

Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics
Caruso Bavisotto C, Cipolla C, Graceffa G, Barone R, Bucchieri F, Bulone D, Cabibi D, Campanella C, Marino Gammazza A, Pitruzzella A, Porcasi R, San Biagio PL, Tomasello G, Conway de Macario E, Macario AJL, Cappello F, Rappa F
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20184496

Recombinant mussel protein Pvfp-5?: A potential tissue bioadhesive
Santonocito R1, Venturella F2,3, Dal Piaz F4, Morando MA3, Provenzano A, Rao E, Costa MA, Bulone D, San Biagio PL, Giacomazza D, Sicorello A, Alfano C, Passantino R, Pastore A
Journal of biological chemistry, 294, 2019
DOI: 10.1074/jbc.RA119.009531

Water Extract of Cryphaea heteromalla (Hedw.) D. Mohr Bryophyte as a Natural Powerful Source of Biologically Active Compounds
Provenzano F, Sánchez JL, Rao E, Santonocito R, Ditta LA, Borrás Linares I, Passantino R, Campisi P, Dia MG, Costa MA, Segura-Carretero A, San Biagio PL, Giacomazza D
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20225560

Biochemical and biophysical characterization of water-soluble pectin from Opuntia ficus-indica and its potential cytotoxic activity
Lefsih K, Giacomazza D, Passantino R, Costa MA, Bulone D, Mangione MR, Guarrasi V, Mingoia F, San Biagio PL, Madani K
Phytochemistry, 154, 2018
DOI: 10.1016/j.phytochem.2018.06.015

Chaperonin of Group I: Oligomeric spectrum and biochemical and biological implications
Vilasi S, Bulone D, Caruso Bavisotto C, Campanella C, Marino Gammazza A, San Biagio PL, Cappello F, Conway de Macario E, Macario AJL
Frontiers in Molecular Biosciences, 4, 2018
DOI: 10.3389/fmolb.2017.00099

Data concerning the rheological behavior of high methoxyl pectin during gelation process
Giacomazza D, Bulone D, San Biagio PL, Marino R, Lapasin R
data in brief, 18, 2018
DOI: 10.1016/j.dib.2018.04.064

Nose-to-brain delivery of insulin enhanced by a nanogel carrier
Picone P, Sabatino MA, Ditta LA, Amato A, San Biagio PL, Mulè F, Giacomazza D, Dispenza C, Di Carlo M
Journal of controlled release, 270, 2018
DOI: 10.1016/j.jconrel.2017.11.040

The precious content of the olive mill wastewater: The protective effects of the antioxidant fraction in cell cultures
Giacomazza D, D'Andrea D, Provenzano A, Picone P, Provenzano F, Guarrasi V, Raimondo M, San Biagio PL, Passantino R, Mangione MR, Di Carlo M, Costa MA
CyTA: journal of food, 16, 2018
DOI: 10.1080/19476337.2018.1458752

The role of sucrose concentration in self-assembly kinetics of high methoxyl pectin
Giacomazza D, Bulone D, San Biagio PL, Marino R, Lapasin R
International journal of biological macromolecules, 112, 2018
DOI: 10.1016/j.ijbiomac.2018.02.103

Bioactive compounds from extra virgin olive oils: Correlation between phenolic content and oxidative stress cell protection
Presti G, Guarrasi V, Gulotta E, Provenzano F, Provenzano A, Giuliano S, Monfreda M, Mangione MR, Passantino R, San Biagio PL, Costa MA, Giacomazza D
Biophysical chemistry , 230, 2017
DOI: 10.1016/j.bpc.2017.09.002

Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti A, Palumbo Piccionello A, Sgarbossa A, Vilasi S, Ricci C, Ghetti F, Spinozzi F, Marino Gammazza A, Giacalone V, Martorana A, Lauria A, Ferrero C, Bulone D, Mangione MR, San Biagio PL, Ortore MG
RSC advances, 7, 2017
DOI: 10.1039/c7ra05300b

Investigation Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.07.008

Pectin from Opuntia ficus indica: Optimization of microwave-assisted extraction and preliminary characterization
Lefsih K, Giacomazza D, Dahmoune F, Mangione MR, Bulone D, San Biagio PL, Passantino R, Costa MA, Guarrasi V, Madani K
Food chemistry, 221, 2017
DOI: 10.1016/j.foodchem.2016.10.073

Physico-chemical and mechanical characterization of in-situ forming xyloglucan gels incorporating a growth factor to promote cartilage reconstruction
Dispenza C, Todaro S, Bulone D, Sabatino MA, Ghersi G, San Biagio PL, Lo Presti C
Materials science & engineering. C, Biomimetic materials, sensors and systems, 70, 2017
DOI: 10.1016/j.msec.2016.09.045

Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog
Spigolon D, Gallagher DT, Velazquez-Campoy A, Bulone D, Narang J, San Biagio PL, Cappello F, Macario AJL, Conway de Macario E, Robb FT
Biochemistry and Biophysics Reports, 12, 2017
DOI: 10.1016/j.bbrep.2017.07.011

Amyloid ?-peptide insertion in liposomes containing GM1-cholesterol domains
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.010

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Aging , 8, 2016
DOI: 10.18632/aging.101004

Data concerning the proteolytic resistance and oxidative stress in LAN5 cells after treatment with BSA hydrogels.
Picone P, Navarra G, Peres C, Contardi M, San Biagio PL, Di Carlo M, Giacomazza D, Militello V
Data in brief, 9, 2016
DOI: 10.1016/j.dib.2016.08.065

Heat- and pH-induced BSA conformational changes, hydrogel formation and application as 3D cell scaffold
Navarra G, Peres C, Contardi M, Picone P, San Biagio PL, Di Carlo M, Giacomazza D, Militello V
Archives of biochemistry and biophysics, 606, 2016
DOI: 10.1016/j.abb.2016.07.020

Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects, 1860, 2016
DOI: 10.1016/j.bbagen.2016.07.019

Ionizing Radiation-Engineered Nanogels as Insulin Nanocarriers for the Development of a New Strategy for the Treatment of Alzheimer's Disease
Pasquale Picone, Lorena Anna Ditta, Maria Antonietta Sabatino, Valeria Militello, Pier Luigi San Biagio, Maria Laura Di Giacinto, Laura Cristaldi, Domenico Nuzzo, Clelia Dispenza, Daniela Giacomazza, Marta Di Carlo
Biomaterials, 80, 2016
DOI: 10.1016/j.biomaterials.2015.11.057

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.006

The complex mechanism of HM pectin self-assembly: A rheological investigation
Giacomazza D.; Bulone D.; San Biagio P.L.; Lapasin R.
Carbohydrate polymers, 146, 2016
DOI: 10.1016/j.carbpol.2016.03.046

Photo-inhibition of A beta fibrillation mediated by a newly designed fluorinated oxadiazole
Mangione, M. R.; Piccionello, A. Palumbo; Marino, C.; Ortore, M. G.; Picone, P.; Vilasi, S.; Di Carlo, M.; Buscemi, S.; Bulone, D.; Biagio, P. L. San
RSC advances , 5, 2015
DOI: 10.1039/c4ra13556c

Temperature-induced self-assembly of degalactosylated xyloglucan at low concentration
Todaro S.; Dispenza C.; Sabatino M.A.; Ortore M.G.; Passantino R.; San Biagio P.L.; Bulone D.
Journal of polymer science. Part B, Polymer physics, 53, 2015
DOI: 10.1002/polb.23895

alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes
Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi
Journal of physical chemistry letters, 5, 2014
DOI: 10.1021/jz501570m

Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis.
Marino Gammazza, Antonella; Rizzo, Manfredi; Citarrella, Roberto; Rappa, Francesca; Campanella, Claudia; Bucchieri, Fabio; Patti, Angelo; Nikolic, Dragana; Cabibi, Daniela; Amico, Giandomenico; Conaldi, Pier Giulio; San Biagio, Pier Luigi; Montalto, Giuse
Cell stress & chaperones, 19, 2014
DOI: 10.1007/s12192-013-0460-9

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Dav
PloS one, 9, 2014
DOI: 10.1371/journal.pone.0097657

Maltose-conjugated chitosans induce macroscopic gelation of pectin solutions at neutral pH
Giacomazza, D.; Sabatino, M. A.; Catena, A.; Leone, M.; San Biagio, P. L.; Dispenza, C.
Carbohydrate polymers, 114, 2014
DOI: 10.1016/j.carbpol.2014.08.014

Seasonal variations of antimicrobial activity and chemical composition of essential oils extracted from three Citrus limon L. Burm. cultivars
Settanni, L. and Randazzo, W. and Palazzolo, E. and Moschetti, M. and Aleo, A. and Guarrasi, V. and Mammina, C. and San Biagio, P. L. and Marra, F. P. and Moschetti, G. and Germanà, M. A.
Natural product research, 28, 2014

alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
Journal of physical chemistry b, 116, 2012
DOI: 10.1021/jp307417x

Alzheimer's disease: biological aspects, therapeutic perspectives and diagnostic tools
M Di Carlo, D Giacomazza, P L San Biagio
Journal of physics. Condensed matter (online), 24, 2012
DOI: 10.1088/0953-8984/24/24/244102

Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases?
Di Carlo M, Giacomazza D, Picone P, Nuzzo D, San Biagio PL.
Free radical research, 46, 2012
DOI: 10.3109/10715762.2012.714466

Entrapment of A Beta 1-40 peptide in unstructured aggregates
Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL
Journal of physics. Condensed matter, 24, 2012
DOI: 10.1088/0953-8984/24/24/244103

Inhibiting effect of alpha(s1)-casein on A beta(1-40) fibrillogenesis
Carrotta R; Canale C; Diaspro A; Trapani A; San Biagio PL; Bulone D
Biochimica et biophysica acta. G, General subjects, 1820, 2012
DOI: 10.1016/j.bbagen.2011.11.010

Multivariate data analysis of thermally treated Sicilian extravirgin olive oils. Coupling of electronic nose, gas chromatography-mass spectroscopy and rheology techniques
Amenta, M; Monge, Me; Lizzarraga, L; Giacomazza, D; Guarrasi, V; SAN BIAGIO, PIER LUIGI; Bulone, D
THE OPEN FOOD SCIENCE JOURNAL, 6, 2012
DOI: 10.2174/1874256401206010024

Rheological characterization and release properties of inulin-based hydrogels
Pitarresi G; Giacomazza D; Triolo D; Giammona G; San Biagio PL
Carbohydrate polymers , 88, 2012
DOI: 10.1016/j.carbpol.2012.01.059

Insulin activated Akt rescues Ab oxidative stress induced cell death by orchestrating molecules trafficking
Picone, P; Giacomazza, D; Vetri, V; Carrotta, R; Militello, V; SAN BIAGIO, PIER LUIGI; Di Carlo, M
AGING CELL (ONLINE), 10, 2011
DOI: 10.1111/j.1474-9726.2011.00724.x

Insulin-activated Akt rescues A? oxidative stress-induced cell death by orchestrating molecular trafficking
Picone P, Giacomazza D, Vetri V, Carrotta R, Militello V, San Biagio PL, Di Carlo M
Aging cell, 10, 2011

Amyloid gels: precocious appearance of elastic properties during the formation of an insulin fibrillar network
Manno M, Giacomazza D, Newman J, Martorana V, San Biagio PL
Langmuir, 26, 2010
DOI: 10.1021/la903340v

Insulin promotes survival of amyloid-beta oligomers neuroblastoma damaged cells via caspase 9 inhibition and Hsp70 upregulation
Di Carlo M, Picone P, Carrotta R, Giacomazza D, San Biagio PL
Journal of biomedicine and biotechnology, 2010, 2010

Irreversible gelation of thermally unfolded lysozyme: structural and mechanical properties of lysozyme aggregates
Raccosta S, Manno M, Bulone D, Giacomazza D, Militello V, Martorana V, San Biagio PL
European biophysics journal with biophysics letters, 39, 2010
DOI: 10.1007/s00249-009-0503-4

Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures.
Picone P, Carrotta R, Montana G, Nobile MR, San Biagio PL, Di Carlo M
Biophysical journal, 96, 2009
DOI: 10.1016/j.bpj.2008.11.056

Protein stability modulated by a conformational effector: effects of trifluoroethanol on bovine serum albumin.
Carrotta R, Manno M, Giordano FM, Longo A, Portale G, Martorana V, Biagio PL
Physical chemistry chemical physics, 11, 2009
DOI: 10.1039/b818687a

Thermal aggregation and ion-induced cold-gelation of Bovine Serum Albumin
Navarra G, Giacomazza D, Leone M, Librizzi F, Militello V, San Biagio PL
European biophysics journal with biophysics letters, 38, 2009
DOI: 10.1007/s00249-008-0389-6

A statistical light scattering approach to separating fast and slow dynamics.
Barthès J.; D. Bulone; M. Manno; V. Martorana; P. L. San Biagio.
European biophysics journal, 36, 2007
DOI: 10.1007/s00249-007-0163-1

Employment of Cationic Solid-Lipid nanoparticles as RNA carriers
Montana G.; Bondì M.L.; Carrotta R.; Picone P.; Craparo E.F.; San Biagio P.L.; Giammona G.; Di Carlo M.
Bioconjugate chemistry, 18, 2007
DOI: 10.1021/bc0601166

Kinetics of different processes in human insulin amyloid formation.
Manno M.; Craparo E.F.; Podestà A.; Bulone D.; Carrotta R.; Martorana V.; Milani P.; Tiana G.; San Biagio P.L.
Journal of Molecular Biology, 366, 2007
DOI: 10.1016/j.jmb.2006.11.008

Large size fibrillar bundles of the alzheimer amyloid beta-protein.
Carrotta R.; J. Barthès; A. Longo; V. Martorana; M. Manno; G. Portale; P. L. San Biagio.
European biophysics journal, 36, 2007
DOI: 10.1007/s00249-007-0164-0

Relation between structural and release properties in a polysaccharide gel system.
Mangione M. R.; D. Giacomazza; G. Cavallaro; D. Bulone (1); V. Martorana; P. L. San Biagio (1).
Biophysical chemistry, 129, 2007
DOI: 10.1016/j.bpc.2007.04.013

Kinetics of insulin aggregation: disentanglement of amyloid fibrillation from large-size cluster formation.
Manno M.; Craparo E.F.; Martorana V.; Bulone D.; San Biagio P.L.
Biophysical journal, 90, 2006
DOI: 10.1529/biophysj.105.077636

The interplay between polyQ and protein context delays aggregation by forming a reservoir of protofibrils
Bulone Donatella; Masino Laura; Thomas David J.; San Biagio Pier Luigi; Pastore Annalisa
PloS one, 1, 2006
DOI: 10.1371/journal.pone.0000111

Toxicity of recombinant beta-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus.
Carrotta R.; Di Carlo M.; Manno M.; Montana G.; Picone P.; Romancino D.; San Biagio P.L.
The FASEB journal, 20, 2006
DOI: 10.1096/fj.06-5716fje

Role of sucrose in pectin gelation: Static and dynamic light scattering experiments
Bulone, D; Martorana, V; Xiao, C; SAN BIAGIO, PIER LUIGI
MACROMOLECULES (PRINT), 35, 2002
DOI: 10.1021/ma0205109

Effects of intermediates on aggregation of native bovine serum albumin.
Bulone, D; Martorana, V; SAN BIAGIO, PIER LUIGI
BIOPHYSICAL CHEMISTRY, 91, 2001
DOI: 10.1016/S0301-4622(01)00155-7