Raboni, S.; Fumagalli, F.; Ceccone, G.; La Spina, R.; Ponti, J.; Mehn, D.; Guerrini, G.; Bettati, S.; Mozzarelli, A.; D'Acunto, M.; Presciuttini, G.; Cristallini, C.; Gabellieri, E.; Cioni, P.
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 653, 2024
DOI: 10.1016/j.ijpharm.2024.123882
HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham
Kellogg Glen, E E; Marabotti, Anna; Spyrakis, Francesca; Mozzarelli, Andrea
FRONTIERS IN MOLECULAR BIOSCIENCES, 10, 2023
DOI: 10.3389/fmolb.2023.1194962
L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase
Marchesani, F; Zangelmi, E; Murtas, G; Costanzi, E; Ullah, R; Peracchi, A; Bruno, S; Pollegioni, L; Mozzarelli, A; Storici, P; Campanini, B
PROTEIN SCIENCE (PRINT), 32, 2023
DOI: 10.1002/pro.4609
Post-Translational Modifications of Histone Variants in the Absence and Presence of a Methionine-Depleting Enzyme in Normal and Cancer Cells
Montalbano, S; Raboni, S; Sidoli, S; Mozzarelli, A; Bettati, S; Buschini, A
CANCERS, 15, 2023
DOI: 10.3390/cancers15020527
The human phosphorylated pathway: a multienzyme metabolic assembly for l-serine biosynthesis
Rabattoni, V; Marchesani, F; Murtas, G; Sacchi, S; Mozzarelli, A; Bruno, S; Peracchi, A; Pollegioni, L; Campanini, B
THE FEBS JOURNAL (ONLINE), 2023
DOI: 10.1111/febs.16787
Enzyme Replacement Therapy for Genetic Disorders Associated with Enzyme Deficiency
Marchetti, Marialaura and Faggiano, Serena and Mozzarelli, Andrea
current medicinal chemistryissn: 0929-8673bentham science publishers, 29, 2022
DOI: 10.2174/0929867328666210526144654
From hemoglobin allostery to hemoglobin-based oxygen carriers
Faggiano S.; Ronda L.; Bruno S.; Abbruzzetti S.; Viappiani C.; Bettati S.; Mozzarelli A.
molecular aspects of medicine, 84, 2022
DOI: 10.1016/j.mam.2021.101050
Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95
Giaccari R.; Marchesani F.; Compari C.; Fisicaro E.; Mozzarelli A.; Campanini B.; Bettati S.; Bruno S.; Faggiano S.
international journal of molecular sciences (print), 23, 2022
DOI: 10.3390/ijms23094959
Stability of a Novel PEGylation Site on a Putative Haemoglobin-Based Oxygen Carrier
Cooper, Ce; Bird, M; Sheng, X; Simons, M; Ronda, L; Mozzarelli, A; Reeder, Bj
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 1395, 2022
DOI: 10.1007/978-3-031-14190-4_48
Targeted Biologics: The New Frontier for Precision Therapy
Mozzarelli, Andrea and Bruno, Stefano and Buehler, Paul W.
current medicinal chemistryissn: 0929-8673bentham science publishers, 29, 2022
DOI: 10.2174/092986732903220103161049
A Key Silencing Histone Mark on Chromatin Is Lost When Colorectal Adenocarcinoma Cells Are Depleted of Methionine by Methionine gamma-Lyase
Raboni, Samanta and Montalbano, Serena and Stransky, Stephanie and Garcia, Benjamin A. and Buschini, Annamaria and Bettati, Stefano and Sidoli, Simone and Mozzarelli, Andrea
frontiers in molecular biosciences, 8, 2021
DOI: 10.3389/fmolb.2021.735303
Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase
Michielon A.; Marchesani F.; Faggiano S.; Giaccari R.; Campanini B.; Bettati S.; Mozzarelli A.; Bruno S.
biochimica et biophysica acta. proteins and proteomicsissn: 1570-9639elsevier, 1869, 2021
DOI: 10.1016/j.bbapap.2020.140544
Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit
Cooper, Chris E. and Bird, Matthew and Sheng, XiaoBo and Choi, Ji-Won and Silkstone, Gary G. A. and Simons, Michelle and Syrett, Natalie and Piano, Riccardo and Ronda, Luca and Bettati, Stefano and Paredi, Gianluca and Mozzarelli, Andrea and Reeder, Brandon J.
frontiers in chemistry, 9, 2021
DOI: 10.3389/fchem.2021.707797
Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality
Cooper, Chris E.; Silkstone, Gary G. A.; Simons, Michelle; Gretton, Svetlana; Rajagopal, Badri S.; Allen-Baume, Victoria; Syrett, Natalie; Shaik, Thoufieq; Popa, Gina; Sheng, XiaoBo; Bird, Matthew; Choi, Ji-Won; Piano, Riccardo; Ronda, Luca; Bettati, Stef
Biomaterials Science, 8, 2020
DOI: 10.1039/c9bm01773a
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor
Magalhaes, Joana; Franko, Nina; Raboni, Samanta; Annunziato, Giannamaria; Tammela, Paivi; Bruno, Agostino; Bettati, Stefano; Mozzarelli, Andrea; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele
Acs Medicinal Chemistry Letters, 11, 2020
DOI: 10.1021/acsmedchemlett.9b00627
Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection ofStaphylococcus aureus
Ronda, Luca; Tonelli, Alessandro; Sogne, Elisa; Autiero, Ida; Spyrakis, Francesca; Pellegrino, Sara; Abbiati, Giorgio; Maffioli, Elisa; Schulte, Carsten; Piano, Riccardo; Cozzini, Pietro; Mozzarelli, Andrea; Bettati, Stefano; Clerici, Francesca; Milani, P
Sensors, 20, 2020
DOI: 10.3390/s20174977
SP-B and SP-C analogues within CHF5633 synthetic surfactant probed by fluorescence labeling
Ronda, Luca; Faggiano, Serena; Paredi, Gianluca; Michielon, Annalisa; Sartor, Franco; Raschini, Annamaria Soliani; Cavatorta, Valeria; Sgarbi, Elisa; Bettati, Stefano; Mozzarelli, Andrea
Journal Of Molecular Liquids, 298, 2020
DOI: 10.1016/j.molliq.2019.111983
ADIFAB fluorescence data used for the quantification of free fatty acids in media at different pH
Faggiano S, Ronda L, Raboni S, Mozzarelli A
Data in brief, 22, 2019
DOI: 10.1016/j.dib.2018.12.006
Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action
Rosa B, Marchetti M, Paredi G, Amenitsch H, Franko N, Benoni R, Giabbai B, De Marino MG, Mozzarelli A, Ronda L, Storici P, Campanini B, Bettati S
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20205219
Is the protein profile of pig Longissimus dorsi affected by gender and diet?
Paredi G, Mori F, de Marino MG, Raboni S, Marchi L, Galati S, Buschini A, Lo Fiego DP, Mozzarelli A
Journal of proteomics, 206, 2019
DOI: 10.1016/j.jprot.2019.103437
The Energy Landscape of Human Serine Racemase
Raboni S, Marchetti M, Faggiano S, Campanini B, Bruno S, Marchesani F, Margiotta M, Mozzarelli A
Frontiers in Molecular Biosciences, 5, 2019
DOI: 10.3389/fmolb.2018.00112
Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers
Simons M, Gretton S, Silkstone GGA, Rajagopal B, Allen-Baume V, Syrett N, Shaik T, Bülow L, Eriksson N, Ronda R, Mozzarelli A, Strader MB, Alayash AI, Reeder BJ, Cooper CE
Bioscience reports, 38, 2018
DOI: 10.1042/BSR20180370
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design
Magalhaes J.; Franko N.; Annunziato G.; Welch M.; Dolan S.K.; Bruno A.; Mozzarelli A.; Armao S.; Jirgensons A.; Pieroni M.; Costantino G.; Campanini B.
Journal of enzyme inhibition and medicinal chemistry, 33, 2018
DOI: 10.1080/14756366.2018.1512596
Engineering methionine ?-lyase from Citrobacter freundii for anticancer activity
Raboni S, Revtovich S, Demitri N, Giabbai B, Storici P, Cocconcelli C, Faggiano S, Rosini E, Pollegioni L, Galati S, Buschini A, Morozova E, Kulikova V, Nikulin A, Gabellieri E, Cioni P, Demidkina T, Mozzarelli A
Biochimica et biophysica acta. Proteins and proteomics, 1866, 2018
DOI: 10.1016/j.bbapap.2018.09.011
Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP
Canosa AV, Faggiano S, Marchetti M, Armao A, Bettati S, Bruno S, Percudani P, Campanini B, Mozzarelli A
Scientific reports , 8, 2018
DOI: 10.1038/s41598-018-27227-1
High- and low-affinity PEGylated hemoglobin-based oxygen carriers: Differential oxidative stress in a Guinea pig transfusion model
Alomari E, Ronda L, Bruno S, Paredi G, Marchetti ML, Bettati S, Olivari D, Fumagalli F, Novelli D, Ristagno G, Latini R, Cooper CE, Reeder BJ, Mozzarelli A
Free radical biology & medicine, 124, 2018
DOI: 10.1016/j.freeradbiomed.2018.06.018
Human serine racemase is nitrosylated at multiple sites
Marchesani F, Bruno S, Paredi G, Raboni S, Campanini B, Mozzarelli A
Biochimica et biophysica acta. Proteins and proteomics, 1866, 2018
DOI: 10.1016/j.bbapap.2018.01.009
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives
Franko N, Grammatoglou K, Campanini B, Costantino G, Jirgensons A, Mozzarelli A
Journal of enzyme inhibition and medicinal chemistry, 33, 2018
DOI: 10.1080/14756366.2018.1504040
Phospholipid components of the synthetic pulmonary surfactant CHF5633 probed by fluorescence spectroscopy
Faggiano S, Ronda L, Raboni S, Sartor F, Cavatorta V, Sgarbi E, Caivano G, Pertile M, Mozzarelli A
International journal of pharmaceutics, 553, 2018
DOI: 10.1016/j.ijpharm.2018.10.045
Protein carbonylation detection methods: A comparison
Alomari EA, Bruno S, Ronda L, Paredi G, Bettati S, Mozzarelli A
Data in brief, 19, 2018
DOI: 10.1016/j.dib.2018.06.088
Soluble and Nanoporous Silica Gel-Entrapped C-freundii Methionine gamma-Lyase
Morozova EA, Kulikova VV, Faggiano S, Raboni S, Gabellieri E, Cioni P, Anufrieva NV, Revtovich SV, Demidkina T, Mozzarelli A
Journal of nanoscience and nanotechnology, 18, 2018
DOI: 10.1166/jnn.2018.14333
Gene cloning, characterization, and cytotoxic activity of methionine ?-lyase from Clostridium novyi
Kulikova; V V;Morozova; E A;Revtovich; S V;Kotlov; M I;Anufrieva; N V;Bazhulina; N P;Raboni S;Faggiano S;Gabellieri E;Cioni P;Belyi; Y F;Mozzarelli A;Demidkina; T V
IUBMB LIFE (PRINT), 69, 2017
DOI: 10.1002/iub.1649
Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form
Bruno S, Margiotta M, Marchesani F, Paredi G, Orlandi V, Faggiano S, Ronda L, Campanini B, Mozzarelli A
Biochimica et biophysica acta. Proteins and proteomics, 1865, 2017
DOI: 10.1016/j.bbapap.2017.01.001
Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex
Benoni R, De Bei O, Paredi GL, Hayes CS, Franko N, Mozzarelli A, Bettati S, Campanini B
FEBS letters, 591, 2017
DOI: 10.1002/1873-3468.12630
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR
Annunziato G, Pieroni M, Benoni R, Campanini B, Pertinhez TA, Pecchini C, Bruno A, Magalhães J, Bettati S, Franko N, Mozzarelli A, Costantino G
Journal of enzyme inhibition and medicinal chemistry, 31, 2016
DOI: 10.1080/14756366.2016.1218486
Insight of Saffron Proteome by Gel-Electrophoresis
Paredi G, Raboni S, Marchesani F, Ordoudi SA, Tsimidou MZ, Mozzarelli A
Molecules , 21, 2016
DOI: 10.3390/molecules21020167
Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of alpha-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase
Pieroni M, Annunziato G, Beato C, Wouters R, Benoni R, Campanini B, Pertinhez TA, Bettati S, Mozzarelli A, Costantino G
Journal of medicinal chemistry, 59, 2016
DOI: 10.1021/acs.jmedchem.5b01775
Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases
Bruno S, Margiotta M, Pinto A, Cullia G, Conti P, De Micheli C, Mozzarelli A
Bioorganic & medicinal chemistry, 24, 2016
DOI: 10.1016/j.bmc.2016.04.033
Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR
Benoni R, Pertinhez TA, Spyrakis F, Davalli S, Pellegrino S, Paredi GL, Pezzotti A, Bettati S, Campanini B, Mozzarelli A
FEBS letters, 590, 2016
DOI: 10.1002/1873-3468.12126
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target
Beato C, Pecchini C, Cocconcelli C, Campanini B, Marchetti ML, Pieroni M, Mozzarelli A, Costantino G
Journal of enzyme inhibition and medicinal chemistry , 31, 2015
DOI: 10.3109/14756366.2015.1057720
Expanding the chemical space of human serine racemase inhibitors
Dellafiora L.; Marchetti M.; Spyrakis F.; Orlandi V.; Campanini B.; Cruciani G.; Cozzini P.; Mozzarelli A.
Bioorganic & medicinal chemistry letters , 25, 2015
DOI: 10.1016/j.bmcl.2015.07.081
Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models
Henry E.R.; Mozzarelli A.; Viappiani C.; Abbruzzetti S.; Bettati S.; Ronda L.; Bruno S.; Eaton W.A.
Biophysical journal , 109, 2015
DOI: 10.1016/j.bpj.2015.04.037
From protein structure to function via single crystal optical spectroscopy
Ronda, Luca; Bruno, Stefano; Bettati, Stefano; Storici, Paola; Mozzarelli, Andrea
Frontiers in Molecular Biosciences , 2, 2015
DOI: 10.3389/fmolb.2015.00012
Immobilization of proteins in silica gel: Biochemical and biophysical properties
Ronda L.[ 1 ]; Bruno S.[ 2 ]; Campanini B.[ 2 ]; Mozzarelli A.[ 2,6,7 ]; Abbruzzetti S.[ 3,8 ]; Viappiani C.[ 4,8 ] ; Cupane A.[ 5 ] ; Levantino M.[ 5 ] ; Bettati S.[ 1,6 ]
Current organic chemistry , 19, 2015
DOI: 10.2174/1385272819666150601211349
Allosteric communication of tryptophan synthase: Functional and regulatory properties of the βS178P mutant
Marabotti, A.; De Biase, D.; Tramonti, A.; Bettati, S.; Mozzarelli, A.
THE JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 2001
DOI: 10.1074/jbc.M011781200
Andrea Mozzarelli
Associate
Full professor in biochemistry since 2000, Department of food and drug sciences, University of Parma. Associated with Cnr, Institute of biophysics, Unit of Pisa, since 2014.
Deputy Director of the Interdepartmental Center SITEIA.PARMA and member of the Biopharmanet-Tec Center, UNIPR. Coordinator of the protein Group, Italian Society of Biochemistry, since 2016.
It carries out scientific activity for the understanding of the relationship structure, dynamics, function and regulation of proteins. He received and receive funding on competitive projects from EU, NIH, Cnr, MIUR. He was PI of the three-year project CNR-RFBR (RUSSIA) on "Methionine gamma lyase as a new antitumor drug”. He has research contracts with pharmaceutical companies.
orcid://0000-0003-3762-0062,
Contact:
- Email andrea.mozzarelli@ibf.cnr.it
- Phone +39-052-1905138
- Location Pisa
Research interests:
- Engineering methionine gamma lyase for anticancer therapy. (Principal investigator)
Further collaborations:
- Tatyana Demidkina (Russian Academy of Science, Mosca, Russia)
- Samanta Raboni (Università di Parma)
- Svetlana Revtovich (Russian Academy of Science, Mosca, Russia)
- Tatyana Demidkina (Russian Academy of Science, Mosca, Russia)
- Paola Storici (Sincrotrone Elettra Trieste)
- Stefano Bettati (Università di Parma)
- Luca Ronda (Università di Parma)
- Stefano Bruno (Università di Parma)
- Barbara Campanini (Università di Parma)
- Annamaria Buschini (Università di Parma)
- Cristiano Viappiani (Università di Parma)
- Chris Cooper (University of Essex, Colchester, UK)
- Simone Sidoli (University of Pennsylvania, Filadelfia, USA)
- William A. Eaton (NIH, Bethesda, USA)
Key publications:
Henry ER, Mozzarelli A, Viappiani C, Abbruzzetti S, Bettati S, Ronda L, Bruno S, Eaton WA (2015)
Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models. Biophys. J 109:1264-1272
Pieroni M, Annunziato G, Beato C, Wouters R, Benoni R, Campanini B, Pertinhez TA, Bettati S, Mozzarelli A, Costantino G (2016) Rational Design, Synthesis and Preliminary Structure-Activity Relationships of alpha-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella Typhimurium O-Acetylserine Sulfhydrylase. J. Med. Chem. 59:2567-2578
Spyrakis F, Ahmed MH, Bayden AS, Cozzini P, Mozzarelli A, Kellogg GE (2017) The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery. J. Med. Chem. 60:6781–6827
Canosa AV, Faggiano S, Marchetti M, Armao A, Bettati S, Bruno S, Percudani P, Campanini B, Mozzarelli A (2018) Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP. Scientific Reports
Raboni S, Revtovich S, Demitri N, Giabbai B, Storici P, Cocconcelli C, Faggiano S, Rosini E, Pollegioni L, Galati S, Buschini A, Morozova E, Kulikova V, Nikulin A, Gabellieri E, Cioni P, Demidkina T, Mozzarelli A (2018) Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity. Biochim Biophys Acta 1866,:1260-1270
Publications (45):
Conjugation to gold nanoparticles of methionine gamma-lyase, a cancer-starving enzyme. Physicochemical characterization of the nanocomplex for prospective nanomedicine applicationsRaboni, S.; Fumagalli, F.; Ceccone, G.; La Spina, R.; Ponti, J.; Mehn, D.; Guerrini, G.; Bettati, S.; Mozzarelli, A.; D'Acunto, M.; Presciuttini, G.; Cristallini, C.; Gabellieri, E.; Cioni, P.
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 653, 2024
DOI: 10.1016/j.ijpharm.2024.123882
HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham
Kellogg Glen, E E; Marabotti, Anna; Spyrakis, Francesca; Mozzarelli, Andrea
FRONTIERS IN MOLECULAR BIOSCIENCES, 10, 2023
DOI: 10.3389/fmolb.2023.1194962
L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase
Marchesani, F; Zangelmi, E; Murtas, G; Costanzi, E; Ullah, R; Peracchi, A; Bruno, S; Pollegioni, L; Mozzarelli, A; Storici, P; Campanini, B
PROTEIN SCIENCE (PRINT), 32, 2023
DOI: 10.1002/pro.4609
Post-Translational Modifications of Histone Variants in the Absence and Presence of a Methionine-Depleting Enzyme in Normal and Cancer Cells
Montalbano, S; Raboni, S; Sidoli, S; Mozzarelli, A; Bettati, S; Buschini, A
CANCERS, 15, 2023
DOI: 10.3390/cancers15020527
The human phosphorylated pathway: a multienzyme metabolic assembly for l-serine biosynthesis
Rabattoni, V; Marchesani, F; Murtas, G; Sacchi, S; Mozzarelli, A; Bruno, S; Peracchi, A; Pollegioni, L; Campanini, B
THE FEBS JOURNAL (ONLINE), 2023
DOI: 10.1111/febs.16787
Enzyme Replacement Therapy for Genetic Disorders Associated with Enzyme Deficiency
Marchetti, Marialaura and Faggiano, Serena and Mozzarelli, Andrea
current medicinal chemistryissn: 0929-8673bentham science publishers, 29, 2022
DOI: 10.2174/0929867328666210526144654
From hemoglobin allostery to hemoglobin-based oxygen carriers
Faggiano S.; Ronda L.; Bruno S.; Abbruzzetti S.; Viappiani C.; Bettati S.; Mozzarelli A.
molecular aspects of medicine, 84, 2022
DOI: 10.1016/j.mam.2021.101050
Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95
Giaccari R.; Marchesani F.; Compari C.; Fisicaro E.; Mozzarelli A.; Campanini B.; Bettati S.; Bruno S.; Faggiano S.
international journal of molecular sciences (print), 23, 2022
DOI: 10.3390/ijms23094959
Stability of a Novel PEGylation Site on a Putative Haemoglobin-Based Oxygen Carrier
Cooper, Ce; Bird, M; Sheng, X; Simons, M; Ronda, L; Mozzarelli, A; Reeder, Bj
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 1395, 2022
DOI: 10.1007/978-3-031-14190-4_48
Targeted Biologics: The New Frontier for Precision Therapy
Mozzarelli, Andrea and Bruno, Stefano and Buehler, Paul W.
current medicinal chemistryissn: 0929-8673bentham science publishers, 29, 2022
DOI: 10.2174/092986732903220103161049
A Key Silencing Histone Mark on Chromatin Is Lost When Colorectal Adenocarcinoma Cells Are Depleted of Methionine by Methionine gamma-Lyase
Raboni, Samanta and Montalbano, Serena and Stransky, Stephanie and Garcia, Benjamin A. and Buschini, Annamaria and Bettati, Stefano and Sidoli, Simone and Mozzarelli, Andrea
frontiers in molecular biosciences, 8, 2021
DOI: 10.3389/fmolb.2021.735303
Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase
Michielon A.; Marchesani F.; Faggiano S.; Giaccari R.; Campanini B.; Bettati S.; Mozzarelli A.; Bruno S.
biochimica et biophysica acta. proteins and proteomicsissn: 1570-9639elsevier, 1869, 2021
DOI: 10.1016/j.bbapap.2020.140544
Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit
Cooper, Chris E. and Bird, Matthew and Sheng, XiaoBo and Choi, Ji-Won and Silkstone, Gary G. A. and Simons, Michelle and Syrett, Natalie and Piano, Riccardo and Ronda, Luca and Bettati, Stefano and Paredi, Gianluca and Mozzarelli, Andrea and Reeder, Brandon J.
frontiers in chemistry, 9, 2021
DOI: 10.3389/fchem.2021.707797
Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality
Cooper, Chris E.; Silkstone, Gary G. A.; Simons, Michelle; Gretton, Svetlana; Rajagopal, Badri S.; Allen-Baume, Victoria; Syrett, Natalie; Shaik, Thoufieq; Popa, Gina; Sheng, XiaoBo; Bird, Matthew; Choi, Ji-Won; Piano, Riccardo; Ronda, Luca; Bettati, Stef
Biomaterials Science, 8, 2020
DOI: 10.1039/c9bm01773a
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor
Magalhaes, Joana; Franko, Nina; Raboni, Samanta; Annunziato, Giannamaria; Tammela, Paivi; Bruno, Agostino; Bettati, Stefano; Mozzarelli, Andrea; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele
Acs Medicinal Chemistry Letters, 11, 2020
DOI: 10.1021/acsmedchemlett.9b00627
Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection ofStaphylococcus aureus
Ronda, Luca; Tonelli, Alessandro; Sogne, Elisa; Autiero, Ida; Spyrakis, Francesca; Pellegrino, Sara; Abbiati, Giorgio; Maffioli, Elisa; Schulte, Carsten; Piano, Riccardo; Cozzini, Pietro; Mozzarelli, Andrea; Bettati, Stefano; Clerici, Francesca; Milani, P
Sensors, 20, 2020
DOI: 10.3390/s20174977
SP-B and SP-C analogues within CHF5633 synthetic surfactant probed by fluorescence labeling
Ronda, Luca; Faggiano, Serena; Paredi, Gianluca; Michielon, Annalisa; Sartor, Franco; Raschini, Annamaria Soliani; Cavatorta, Valeria; Sgarbi, Elisa; Bettati, Stefano; Mozzarelli, Andrea
Journal Of Molecular Liquids, 298, 2020
DOI: 10.1016/j.molliq.2019.111983
ADIFAB fluorescence data used for the quantification of free fatty acids in media at different pH
Faggiano S, Ronda L, Raboni S, Mozzarelli A
Data in brief, 22, 2019
DOI: 10.1016/j.dib.2018.12.006
Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action
Rosa B, Marchetti M, Paredi G, Amenitsch H, Franko N, Benoni R, Giabbai B, De Marino MG, Mozzarelli A, Ronda L, Storici P, Campanini B, Bettati S
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20205219
Is the protein profile of pig Longissimus dorsi affected by gender and diet?
Paredi G, Mori F, de Marino MG, Raboni S, Marchi L, Galati S, Buschini A, Lo Fiego DP, Mozzarelli A
Journal of proteomics, 206, 2019
DOI: 10.1016/j.jprot.2019.103437
The Energy Landscape of Human Serine Racemase
Raboni S, Marchetti M, Faggiano S, Campanini B, Bruno S, Marchesani F, Margiotta M, Mozzarelli A
Frontiers in Molecular Biosciences, 5, 2019
DOI: 10.3389/fmolb.2018.00112
Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers
Simons M, Gretton S, Silkstone GGA, Rajagopal B, Allen-Baume V, Syrett N, Shaik T, Bülow L, Eriksson N, Ronda R, Mozzarelli A, Strader MB, Alayash AI, Reeder BJ, Cooper CE
Bioscience reports, 38, 2018
DOI: 10.1042/BSR20180370
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design
Magalhaes J.; Franko N.; Annunziato G.; Welch M.; Dolan S.K.; Bruno A.; Mozzarelli A.; Armao S.; Jirgensons A.; Pieroni M.; Costantino G.; Campanini B.
Journal of enzyme inhibition and medicinal chemistry, 33, 2018
DOI: 10.1080/14756366.2018.1512596
Engineering methionine ?-lyase from Citrobacter freundii for anticancer activity
Raboni S, Revtovich S, Demitri N, Giabbai B, Storici P, Cocconcelli C, Faggiano S, Rosini E, Pollegioni L, Galati S, Buschini A, Morozova E, Kulikova V, Nikulin A, Gabellieri E, Cioni P, Demidkina T, Mozzarelli A
Biochimica et biophysica acta. Proteins and proteomics, 1866, 2018
DOI: 10.1016/j.bbapap.2018.09.011
Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP
Canosa AV, Faggiano S, Marchetti M, Armao A, Bettati S, Bruno S, Percudani P, Campanini B, Mozzarelli A
Scientific reports , 8, 2018
DOI: 10.1038/s41598-018-27227-1
High- and low-affinity PEGylated hemoglobin-based oxygen carriers: Differential oxidative stress in a Guinea pig transfusion model
Alomari E, Ronda L, Bruno S, Paredi G, Marchetti ML, Bettati S, Olivari D, Fumagalli F, Novelli D, Ristagno G, Latini R, Cooper CE, Reeder BJ, Mozzarelli A
Free radical biology & medicine, 124, 2018
DOI: 10.1016/j.freeradbiomed.2018.06.018
Human serine racemase is nitrosylated at multiple sites
Marchesani F, Bruno S, Paredi G, Raboni S, Campanini B, Mozzarelli A
Biochimica et biophysica acta. Proteins and proteomics, 1866, 2018
DOI: 10.1016/j.bbapap.2018.01.009
Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives
Franko N, Grammatoglou K, Campanini B, Costantino G, Jirgensons A, Mozzarelli A
Journal of enzyme inhibition and medicinal chemistry, 33, 2018
DOI: 10.1080/14756366.2018.1504040
Phospholipid components of the synthetic pulmonary surfactant CHF5633 probed by fluorescence spectroscopy
Faggiano S, Ronda L, Raboni S, Sartor F, Cavatorta V, Sgarbi E, Caivano G, Pertile M, Mozzarelli A
International journal of pharmaceutics, 553, 2018
DOI: 10.1016/j.ijpharm.2018.10.045
Protein carbonylation detection methods: A comparison
Alomari EA, Bruno S, Ronda L, Paredi G, Bettati S, Mozzarelli A
Data in brief, 19, 2018
DOI: 10.1016/j.dib.2018.06.088
Soluble and Nanoporous Silica Gel-Entrapped C-freundii Methionine gamma-Lyase
Morozova EA, Kulikova VV, Faggiano S, Raboni S, Gabellieri E, Cioni P, Anufrieva NV, Revtovich SV, Demidkina T, Mozzarelli A
Journal of nanoscience and nanotechnology, 18, 2018
DOI: 10.1166/jnn.2018.14333
Gene cloning, characterization, and cytotoxic activity of methionine ?-lyase from Clostridium novyi
Kulikova; V V;Morozova; E A;Revtovich; S V;Kotlov; M I;Anufrieva; N V;Bazhulina; N P;Raboni S;Faggiano S;Gabellieri E;Cioni P;Belyi; Y F;Mozzarelli A;Demidkina; T V
IUBMB LIFE (PRINT), 69, 2017
DOI: 10.1002/iub.1649
Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form
Bruno S, Margiotta M, Marchesani F, Paredi G, Orlandi V, Faggiano S, Ronda L, Campanini B, Mozzarelli A
Biochimica et biophysica acta. Proteins and proteomics, 1865, 2017
DOI: 10.1016/j.bbapap.2017.01.001
Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex
Benoni R, De Bei O, Paredi GL, Hayes CS, Franko N, Mozzarelli A, Bettati S, Campanini B
FEBS letters, 591, 2017
DOI: 10.1002/1873-3468.12630
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR
Annunziato G, Pieroni M, Benoni R, Campanini B, Pertinhez TA, Pecchini C, Bruno A, Magalhães J, Bettati S, Franko N, Mozzarelli A, Costantino G
Journal of enzyme inhibition and medicinal chemistry, 31, 2016
DOI: 10.1080/14756366.2016.1218486
Insight of Saffron Proteome by Gel-Electrophoresis
Paredi G, Raboni S, Marchesani F, Ordoudi SA, Tsimidou MZ, Mozzarelli A
Molecules , 21, 2016
DOI: 10.3390/molecules21020167
Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of alpha-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase
Pieroni M, Annunziato G, Beato C, Wouters R, Benoni R, Campanini B, Pertinhez TA, Bettati S, Mozzarelli A, Costantino G
Journal of medicinal chemistry, 59, 2016
DOI: 10.1021/acs.jmedchem.5b01775
Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases
Bruno S, Margiotta M, Pinto A, Cullia G, Conti P, De Micheli C, Mozzarelli A
Bioorganic & medicinal chemistry, 24, 2016
DOI: 10.1016/j.bmc.2016.04.033
Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR
Benoni R, Pertinhez TA, Spyrakis F, Davalli S, Pellegrino S, Paredi GL, Pezzotti A, Bettati S, Campanini B, Mozzarelli A
FEBS letters, 590, 2016
DOI: 10.1002/1873-3468.12126
Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target
Beato C, Pecchini C, Cocconcelli C, Campanini B, Marchetti ML, Pieroni M, Mozzarelli A, Costantino G
Journal of enzyme inhibition and medicinal chemistry , 31, 2015
DOI: 10.3109/14756366.2015.1057720
Expanding the chemical space of human serine racemase inhibitors
Dellafiora L.; Marchetti M.; Spyrakis F.; Orlandi V.; Campanini B.; Cruciani G.; Cozzini P.; Mozzarelli A.
Bioorganic & medicinal chemistry letters , 25, 2015
DOI: 10.1016/j.bmcl.2015.07.081
Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models
Henry E.R.; Mozzarelli A.; Viappiani C.; Abbruzzetti S.; Bettati S.; Ronda L.; Bruno S.; Eaton W.A.
Biophysical journal , 109, 2015
DOI: 10.1016/j.bpj.2015.04.037
From protein structure to function via single crystal optical spectroscopy
Ronda, Luca; Bruno, Stefano; Bettati, Stefano; Storici, Paola; Mozzarelli, Andrea
Frontiers in Molecular Biosciences , 2, 2015
DOI: 10.3389/fmolb.2015.00012
Immobilization of proteins in silica gel: Biochemical and biophysical properties
Ronda L.[ 1 ]; Bruno S.[ 2 ]; Campanini B.[ 2 ]; Mozzarelli A.[ 2,6,7 ]; Abbruzzetti S.[ 3,8 ]; Viappiani C.[ 4,8 ] ; Cupane A.[ 5 ] ; Levantino M.[ 5 ] ; Bettati S.[ 1,6 ]
Current organic chemistry , 19, 2015
DOI: 10.2174/1385272819666150601211349
Allosteric communication of tryptophan synthase: Functional and regulatory properties of the βS178P mutant
Marabotti, A.; De Biase, D.; Tramonti, A.; Bettati, S.; Mozzarelli, A.
THE JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 2001
DOI: 10.1074/jbc.M011781200