Rosanna Migliore

Research staff

PhD in Theoretical Physics at the University of Palermo in 2004. Until 2010, my research interests were focused on superconducting mesoscopic devices interacting with quantized electromagnetic fields. Currently my main field of interest is computational neuroscience, with focus on detailed modeling of neurons and small networks (mainly from hippocampus), effects of dendritic ionic channels on firing properties and synaptic integration, kinetic models of synaptic transmission and plasticity.

orcid://0000-0001-9034-7849,

Contact:

- Email rosanna.migliore@ibf.cnr.it
- Phone +39-091-6809604
- Location Palermo

Website:

http://www.pa.ibf.cnr.it/personale/migliore

Research interests:

- Computational Neurosciences

Further collaborations:

- E. Cherubini, European Brain Research Institute, Rome (Italy)
- M. Taglialatela, Department of Neuroscience, University of Naples Federico II, Naples (Italy)
- Romani, C.A. Rossert, J.-D. Courcol, W. Van Geit, E. Muller, F. Schürmann, Blue Brain Project, École Polytechnique Féderale de Lausanne Biotech Campus, Geneva (Switzerland)
- Szabolcs Kali, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest (Hungary)
- Ulrich G. Hofmann, Kevin Joseph, Section of Neuroelectronic Systems, University Medical Center Freiburg (Germany)
- Helene Marie, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne (France)
- Volkmar Lessmann, Otto-von-Guericke-Universität, Institute for Physiology, Magdeburg (Germany)

Publications (16):

Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region
Romani, A.; Antonietti, A.; Bella, D.; Budd, J.; Giacalone, E.; Kurban, K.; Saray, S.; Abdellah, M.; Arnaudon, A.; Boci, E.; Colangelo, C.; Courcol, J. -D.; Delemontex, T.; Ecker, A.; Falck, J.; Favreau, C.; Gevaert, M.; Hernando, J. B.; Herttuainen, J.; Ivaska, G.; Kanari, L.; Kaufmann, A. -K.; King, J. G.; Kumbhar, P.; Lange, S.; Lu, H.; Lupascu, C. A.; Migliore, R.; Petitjean, F.; Planas, J.; Rai, P.; Ramaswamy, S.; Reimann, M. W.; Riquelme, J. L.; Guerrero, N. R.; Shi, Y.; Sood, V.; Sy, M. F.; Van Geit, W.; Vanherpe, L.; Freund, T. F.; Mercer, A.; Muller, E.; Felix, S.; Thomson, A. M.; Migliore, M.; Kali, S.; Markram, H.
PLOS BIOLOGY, 22, 2024
DOI: 10.1371/journal.pbio.3002861

Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs
Vitale, Paola; Librizzi, Fabio; Vaiana Andrea, C.; Capuana, Elisa; Pezzoli, Maurizio; Shi, Ying; Romani, Armando; Migliore, Michele; Migliore, Rosanna
FRONTIERS IN CELLULAR NEUROSCIENCE, 2023

Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs
Bianchi, Daniela; Migliore, Rosanna; Vitale, Paola; Garad, Machhindra; Pousinha, Paula A.; Marie, Helene; Lessmann, Volkmar; Migliore, Michele
biophysical journal (print), 121, 2022
DOI: 10.1016/j.bpj.2022.01.002

Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer's Disease
Vitale P.; Salgueiro-Pereira A.R.; Lupascu C.A.; Willem M.; Migliore R.; Migliore M.; Marie H.
frontiers in aging neuroscience, 13, 2021
DOI: 10.3389/fnagi.2021.668948

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data
Saray, Sara1,2; Roessert, Christian A3.; Appukuttan, Shailesh4; Migliore, Rosanna5; Vitale, Paola5; Lupascu, Carmen A.5; Bologna, Luca L.5; Van Geit, Werner3; Romani, Armando3; Davison, Andrew P4.; Muller, Eilif3,6,7,8; Freund, Tamas F.1,2; Kali, Szabolcs1,2
plos computational biologyissn: 1553-734xpublic library of science,, 17, 2021
DOI: 10.1371/journal.pcbi.1008114

Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1
John P McCauley, Maurice A Petroccione, Lianna Y D'Brant, Gabrielle C Todd, Nurat Affinnih, Justin J Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A Sousa, Rose M De Guzman, Rosanna Migliore, Alexey Brazhe, Richard D Leapman, Alexander Khmaladze, Alexey
CELL REPORTS, 33, 2020
DOI: 10.1016/j.celrep.2020.108255

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow
Migliore R, Lupascu CA, Bologna LL, Romani A, Courcol JD, Antonel S, Van Geit WAH, Thomson AM, Mercer A, Lange S, Falck J, Rössert CA, Shi Y, Hagens O, Pezzoli M, Freund TF, Kali S, Muller EB, Schürmann F, Markram H, Migliore M
PLoS computational biology, 14, 2018
DOI: 10.1371/journal.pcbi.1006423

The possible consequences for cognitive functions of external electric fields at power line frequency on hippocampal CA1 pyramidal neurons
Migliore R, De Simone G, Leinekugel X, Migliore M
European journal of neuroscience, 45, 2017
DOI: 10.1111/ejn.13325

A general procedure to study subcellular models of transsynaptic signaling at inhibitory synapses
Lupascu CA, Morabito A, Merenda E, Marinelli S, Marchetti C, Migliore R, Cherubini E, Migliore M
Frontiers in neuroinformatics, 10, 2016
DOI: 10.3389/fninf.2016.00023

Premature changes in neuronal excitability account for hippocampal network impairment and autistic-like behavior in neonatal BTBR T plus tf/J mice
Cellot G, Maggi L, Di Castro MA, Catalano M, Migliore R, Migliore M, Scattoni ML, Calamandrei G, Cherubini E
Scientific reports , 6, 2016
DOI: 10.1038/srep31696

Early-Onset Epileptic Encephalopathy Caused by Gain-of-Function Mutations in the Voltage Sensor of K(v)7.2 and K(v)7.3 Potassium Channel Subunits
Miceli, Francesco; Soldovieri, Maria Virginia; Ambrosino, Paolo; De Maria, Michela; Migliore, Michele; Migliore, Rosanna; Taglialatela, Maurizio
Journal of neuroscience, 35, 2015
DOI: 10.1523/JNEUROSCI.4423-14.2015

Effect of the initial synaptic state on the probability to induce long-term potentiation and depression
Migliore, Michele; De Simone, Giada; Migliore, Rosanna
Biophysical journal , 108, 2015
DOI: 10.1016/j.bpj.2014.12.048

Resonant effects in a SQUID qubit subjected to nonadiabatic changes
Chiarello F.; Spilla S.; Castellano M.G.; Cosmelli C.; Messina A.; Migliore R.; Napoli A.; Torrioli G.
Physical review. B, Condensed matter and materials physics , 89, 2014
DOI: 10.1103/PhysRevB.89.134506

Know Your Current I-h: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations
Migliore M; Migliore R
PloS one, 7, 2012
DOI: 10.1371/journal.pone.0036867

A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior
Migliore M, De Blasi I, Tegolo D, Migliore R
Neural networks, 24, 2011

Dissipative effects on a generation scheme of a W state in an array of coupled Josephson junctions
Migliore R, Scala M, Napoli A, Yuasa K, Nakazato H, Messina A
Journal of physics b-atomic molecular and optical physics, 44, 2011