Mauro Manno

Research staff

Mauro Manno is senior researcher at CNR Institute of Biophysics; author of patents and several peer reviewed publications (H-index 27); contributed to int’l conferences with several abstract or invited lectures; editorial board of Scientific Reports and other journals.
Main education and work experiences: 2017, Le Studium Fellow at Univ. Orléans/CNRS-ICOA, Orléans (France), award from SMART LOIRE VALLEY Fellowships Program, funded by H2020-MSCA Action; 2010, Visiting scientist a CIMR, University of Cambridge (UK); 2000, PhD in Fisica, Università di Palermo; 1998, Visiting Scientist a M.I.T., Cambridge, MA (USA); 1996, Laurea (MD) in Fisica, Università di Palermo (110/110 cum laude).
Current research interests are: (i) stability of biomolecules and pathways leading to self-assembly of biologically relevant structures; (ii) mechanisms of inactivation of proteins involved in serpinopathies, a class of genetic conformational diseases; (ii) structural and mechanical properties of extracellular nanovescicles from human or natural sources, involved in physiological and oncogenic processes, as well as their engineering and biotechnological exploitation.
MM is founder and Adm board of the innovative start-up EVE-Biofactory.

orcid://0000-0001-9843-0428, ncbi://56463429

Contact:

- Email mauro.manno@cnr.it
- Phone +39-091-6809305
- Location Palermo

Research interests:

- Molecular bases of serpinopathies (Principal investigator)
- Characterisation of extracellular vescicles (Principal investigator)
- Laboratory for Advanced and Scattering Technologies (LAST) (Principal investigator)
- BOW – Biogenic Organotropic Wetsuits (Principal investigator)
- Cell-based technologies and bioactives for research and innovation (Cell-Tech Hub) (Principal investigator)
- Production, Purification, Mutagenesis and Characterization of proteins expressed in E. coli
- Model Membrane Systems and Interaction Studies

Further collaborations:

- Antonella Bongiovanni (CNR-IRIB, Palermo, Italy)
- Paolo Colombo (CNR-IRIB, Palermo, Italy)
- Gabriella Pocsfalvi (CNR-IBBR, Napoli, Italy)
- Elia Di Schiavi (CNR-IBBR, Napoli, Italy)
- Giovanna Liguori (CNR-IGB, Napoli, Italy)
- Francesco Valle (CNR-ISMN, Bologna, Italy)
- Valeria Vetri (University of Palermo, Palermo, Italy)
- Antonio Emanuele (University of Palermo, Palermo, Italy)
- Paolo Bergese (University of Brescia, Brescia, Italy)
- Annalisa Redeghieri (University of Brescia, Brescia, Italy)
- Anna Fra (University of Brescia, Brescia, Italy)
- Debora Berti (University of Florence, Firenze, Italy)
- Elena Miranda (University of Rome La Sapienza, Roma, Italy)
- Stefano Ricagno (University of Milan, Milano, Italy)
- Nicolas Touzet (ITS, Sligo, Ireland)
- Katharina Landfester (Max Plank Institute for polymer science, Mainz, Germany)
- Svenja Morsback (Max Plank Institute for polymer science, Mainz, Germany)
- Paolo Arosio (ETH, Zurich, Switzerland)
- Veronika Kraglj-Ilic (University of Ljubljana, Ljubljana, Slovenia)
- Ales Ilic (University of Ljubljana, Ljubljana, Slovenia)
- Jose Riva (University of Santiago, Santiago, Spain)
- Sebastiano Di Bucchianico (Helmholtz Zentrum, Munchen, Germany)
- Giovanna Galliciotti (University Medical Center Eppendorf, Hamburg, Germany)
- Irene Martinez (University of Murcia, Murcia, Spain)
- James Irving (UCL, London, UK)
- David A. Lomas (UCL, London, UK)
- Blanca Rodriguez (Zabala Innovation Consulting, Pamplona, Spain)
- Paolo Di stefano (Day One, Roma, Italy)

Financial support:

- September 2023 - September 2025: Protein Loaded extracellular vesicles As Next generation Therapeutics (PLANT), funded by the Italian Ministry of University and Research under the PRIN 2022 program (Project code 2022TF4BKK). [Role in the project: P.I. of the project]
- November 2022 - October 2025: European Brain ReseArch INfrastructureS-Italy (EBRAINS-Italy), funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan (NRRP), Project code IR0000011. [Role in the project: P.I. of Palermo IBFb-PA unit]
- November 2022 - October 2025: National Center for Gene Therapy and Drugs based on RNA Technology, funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan (NRRP), Project code CN00000041. [Role in the project: P.I. of IBF-PA unit]
- October 2022 - September 2025: Sicilian MicronanoTech Research And Innovation Center (SAMOTHRACE), funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan (NRRP), Project code ECS00000022. [Role in the project: P.I. of IBF unit]
- November 2020 - October 2024: Biogenic Organotropic Wetsuit (BOW), funded by the European Union under the FET Proactive Horizon 2020 research and innovation programme, grant agreements N. 952183. [Role in the project: Task leader and P.I. of IBF unit]
- July 2022 - December 2022: "Beyond Nano Life Science”, funded by The CNR “Biannual program on research infrastructure (Decree CNR n.136/2020-Progetto n.41). [Role in the project: P.I. of IBF unit]
- September 2018 - February 2022: Extracellular vesicles from a natural source for tailor-made nanomaterials (Ves4US), funded by the European Union under the FET Open Horizon 2020 research and innovation programme, grant agreements N. 801338. [Role in the project: Task leader and P.I. of IBF unit]
- October 2016 - October 2017: The role of glycosylation in the functional activity and pathological consequences of serpin proteins, award from Le Studium, the SMART LOIRE VALLEY Fellowships Programme, funded from the EU’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Action. [Fellowship at CNRS-ICOA & Univ. Orléans]
- April 2014 - October 2016: Molecular and Cellular Bases of Serpin Conformational Diseases (MoSe), funded by the Fondazione Cariplo, Project N. 2013-0795. [Role in the project: P.I. of IBF unit]
- November 2011 - December 2015: Role of Neuroserpin in Familial Encephalopathy with Neuroserpin Inclusion Bodies, funded by the Fondazione Telethon, Project N. GGP11057. [Role in the project: P.I. of IBF unit]

Key publications:

G. Adamo, D. Fierli, D. P. Romancino, S. Picciotto, M. E. Barone, A. Aranyos, D. Bozic, S. Morsbach, S. Raccosta, C. Stanly, C. Paganini, M. Y. Gai, A. Cusimano, V. Martorana, R. Noto, R. Carrotta, F. Librizzi, L. Randazzo, R. Parkes, U. Capasso Palmiero, E. Rao, A. Paterna, P. Santonicola, A. Iglic, L. Corcuera, A. Kisslinger, E. Di Schiavi, G. Liguori, K. Landfester, V. Kralj-Iglic, P. Arosio, G. Pocsfalvi, N. Touzet, M. Manno, A. Bongiovanni. Nanoalgosomes: Introducing extracellular vesicles produced by microalgae. Journal of Extracellular Vesicles 10, e12081. doi: 10.1002/jev2.12081

Noto, R., Santangelo, M. G., Ricagno, S., Mangione, M. R., Levantino, M., Pezzullo, M., Martorana, V., Cupane, A., Bolognesi, M., Manno, M. 2012. The tempered Polymerization of Numan Neuroserpin. PLoS ONE 7:e32444(1-12). doi:10.1371/journal.pone.0032444

D. P. Romancino, V. Buffa, S. Caruso, I. Ferrara, S. Raccosta, A. Notaro, Y. Campos, R. Noto, V. Martorana, A. Cupane, A. Giallongo, A. d'Azzo, M. Manno, A. Bongiovanni. Palmitoylation is a post-translational modification of Alix regulating the membrane organization of exosome-like small extracellular vesicles. Biochim. Biophys. Acta - General Subjects 1862, 2879-2887, 2018. doi:10.1016/j.bbagen.2018.09.004

S. Picciotto, M. E. Barone, D. Fierli, A. Aranyos, G. Adamo, D. Bozic, D. P. Romancino, C. Stanly, R. Parkes, S. Morsbach, S. Raccosta, C. Paganini, A. Cusimano, V. Martorana, R. Noto, R. Carrotta, F. Librizzi, U. Capasso Palmiero, P. Santonicola, A. Iglic, M. Y. Gai, L. Corcuera, A. Kisslinger, E. Di Schiavi, K. Landfester, G. Liguori, V. Kralj-Iglic, P. Arosio, G. Pocsfalvi, M. Manno, N. Touzet, A. Bongiovanni. Isolation of extracellular vesicles from microalgae: towards the production of sustainable and natural nanocarriers of bioactive compounds. Biomaterials Science 9, 2917-2930. doi: 10.1039/d0bm01696a

M. Manno, E. F. Craparo, A. Podestà, D. Bulone, R. Carrotta, V. Martorana, G. Tiana, and P. L. San Biagio. 2007. Kinetics of Different Processes in Human Insulin Amyloid Formation. J. Mol. Biol. 366, 258 274. doi:10.1016/j.jmb.2006.11.008

Publications (50):

DetectEV: A functional enzymatic assay to assess integrity and bioactivity of extracellular vesicles
Adamo, Giorgia; Picciotto, Sabrina; Gargano, Paola; Paterna, Angela; Raccosta, Samuele; Rao, Estella; Romancino, Daniele Paolo; Ghersi, Giulio; Manno, Mauro; Salamone, Monica; Bongiovanni, Antonella
JOURNAL OF EXTRACELLULAR VESICLES, 14, 2025
DOI: 10.1002/jev2.70030

A decision-making tool to navigate through Extracellular Vesicle research and product development
Loria, Francesca; Picciotto, Sabrina; Adamo, Giorgia; Zendrini, Andrea; Raccosta, Samuele; Manno, Mauro; Bergese, Paolo; Liguori, Giovanna L.; Bongiovanni, Antonella; Zarovni, Nataša
JOURNAL OF EXTRACELLULAR VESICLES, 2024
DOI: 10.1101/2023.11.16.567368

Antioxidant properties and bioactivity of three marine microalgae on human cancer cell lines
Herbert, H.; Parkes, R.; Barone, M. E.; Mcdonnell, A.; Picciotto, S.; Adamo, G.; Paterna, A.; Manno, M.; Bongiovanni, A.; Touzet, N.; Campion, E.
Applied Phycology, 5, 2024
DOI: 10.1080/26388081.2024.2382146

Effects of Cultivation Stress on the Glaucophyte Cyanophora paradoxa and Bioactive Potential in Human Cancer Cell Lines
Herbert, H.; Parkes, R.; Barone, M. E.; Picciotto, S.; Adamo, G.; Paterna, A.; Manno, M.; Bongiovanni, A.; Campion, E.; Touzet, N.
PHYCOLOGIA, 63, 2024
DOI: 10.1080/00318884.2024.2330341

Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties
Adamo, Giorgia; Santonicola, Pamela; Picciotto, Sabrina; Gargano, Paola; Nicosia, Aldo; Longo, Valeria; Aloi, Noemi; Romancino, Daniele; Paterna, Angela; Rao, Estella; Raccosta, Samuele; Noto, Rosina; Salamone, Monica; Deidda, Irene; Costa, Salvatore; DI SANO, Caterina; Zampi, Giuseppina; Morsbach, Svenja; Landfester, Katharina; Colombo, Paolo; Wei, Mingxing; Bergese, Paolo; Touzet, Nicolas; Manno, Mauro; DI SCHIAVI, Elia; Bongiovanni, Antonella
COMMUNICATIONS BIOLOGY, 7, 2024
DOI: 10.1038/s42003-024-06612-9

alphaS1-Casein administration to a C. elegans model of Alzheimer's disease through proteoliposome delivery
Carrotta, Rita; Paterna, Angela; Santonicola, Pamela; DI PRIMA, Giulia; Rao, Estella; Raccosta, Samuele; Zampi, Giuseppina; Oscar, Moran; Manno, Mauro; DI SCHIAVI, Elia; Librizzi, Fabio
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 52, 2023

High-Yield Separation of Extracellular Vesicles Using Programmable Zwitterionic Coacervates
Paganini, Carolina; Capasso Palmiero, Umberto; Picciotto, Sabrina; Molinelli, Alessandro; Porello, Ilaria; Adamo, Giorgia; Manno, Mauro; Bongiovanni, Antonella; Arosio, Paolo
SMALL (WEINH., PRINT), 2023
DOI: 10.1002/smll.202204736

αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer’s Disease
Paterna, A.; Santonicola, P.; Di Prima, G.; Rao, E.; Raccosta, S.; Zampi, G.; Russo, C.; Moran, O.; Manno, M.; Di Schiavi, E.; Librizzi, F.; Carrotta, R.
ACS CHEMICAL NEUROSCIENCE, 14, 2023
DOI: 10.1021/acschemneuro.3c00239

Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans
Picciotto, Sabrina; Santonicola, Pamela; Paterna, Angela; Rao, Estella; Raccosta, Samuele; Romancino Daniele, Paolo; Noto, Rosina; Touzet, Nicolas; Manno, Mauro; DI SCHIAVI, Elia; Bongiovanni, Antonella; Adamo, Giorgia
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 10, 2022
DOI: 10.3389/fbioe.2022.830189

The Possible Role of the Type I Chaperonins in Human Insulin Self-Association
Pizzo, Federica; Mangione, MARIA ROSALIA; Librizzi, Fabio; Manno, Mauro; Martorana, Vincenzo; Noto, Rosina; Vilasi, Silvia
LIFE, 12, 2022
DOI: 10.3390/life12030448

Isolation of extracellular vesicles from microalgae: Towards the production of sustainable and natural nanocarriers of bioactive compounds
Picciotto, Sabrina; Barone, Maria E.; Fierli, David; Aranyos, Anita; Adamo, Giorgia; Bo?i?, Darja; Romancino, Daniele P.; Stanly, Christopher; Parkes, Rachel; Morsbach, Svenja; Raccosta, Samuele; Paganini, Carolina; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Capasso Palmiero, Umberto; Santonicola, Pamela; Igli?, Ales; Gai, Meiyu; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Landfester, Katharina; Liguori, Giovanna L.; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Manno, Mauro; Touzet, Nicolas; Bongiovanni, Antonella
biomaterials science (print)issn: 2047-4830royal society of chemistry, 9, 2021
DOI: 10.1039/d0bm01696a

N-Glycosylation as a Tool to Study Antithrombin Secretion, Conformation, and Function
Aguila, Sonia; Noto, Rosina; Luengo-Gil, Gines; Espin, Salvador; Bohdan, Nataliya; de la Morena-barrio, Maria Eugenia; Penas, Julia; Rodenas, Maria Carmen; Vicente, Vicente; Corral, Javier; Manno, Mauro; Martinez-Martinez, Irene
international journal of molecular sciences (online)issn: 1422-0067mdpi center,, 22, 2021
DOI: 10.3390/ijms22020516

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae
Adamo, Giorgia; Fierli, David; Romancino, Daniele P.; Picciotto, Sabrina; Barone, Maria E.; Aranyos, Anita; Bo?i?, Darja; Morsbach, Svenja; Raccosta, Samuele; Stanly, Christopher; Paganini, Carolina; Gai, Meiyu; Cusimano, Antonella; Martorana, Vincenzo; Noto, Rosina; Carrotta, Rita; Librizzi, Fabio; Randazzo, Loredana; Parkes, Rachel; Capasso Palmiero, Umberto; Rao, Estella; Paterna, Angela; Santonicola, Pamela; Igli?, Ales; Corcuera, Laura; Kisslinger, Annamaria; Di Schiavi, Elia; Liguori, Giovanna L.; Landfester, Katharina; Kralj-Igli?, Veronika; Arosio, Paolo; Pocsfalvi, Gabriella; Touzet, Nicolas; Manno, Mauro; Bongiovanni, Antonella
journal of extracellular vesiclesissn: 2001-3078järfälla : co-action pub., 10, 2021
DOI: 10.1002/jev2.12081

Preliminary results of citraves(TM) effects on low density lipoprotein cholesterol and waist circumference in healthy subjects after 12 weeks: A pilot open-label study
Raimondo, S. and Nikolic, D. and Conigliaro, A. and Giavaresi, G. and Sasso, B.L. and Giglio, R.V. and Chianetta, R. and Manno, M. and Raccosta, S. and Corleone, V. and Ferrante, G. and Citarrella, R. and Rizzo, M. and De Leo, G. and Ciaccio, M. and Montalto, G. and Alessandro, R.
metabolitesissn: 2218-1989molecular diversity preservation international, 11, 2021
DOI: 10.3390/metabo11050276

Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence-Based Microfluidic Diffusion Sizing
Paganini, Carolina; Hettich, Britta; Kopp, Marie R.G.; Eördögh, Adam; Capasso Palmiero, Umberto; Adamo, Giorgia; Touzet, Nicolas; Manno, Mauro; Bongiovanni, Antonella; Rivera-Fuentes, Pablo; Leroux, Jean Christophe; Arosio, Paolo
advanced healthcare materials (print)issn: 2192-2640wiley-vch, 2021
DOI: 10.1002/adhm.202100021

Scaling concepts in serpin polymer physics
Raccosta S.; Librizzi F.; Jagger A.M.; Noto R.; Martorana V.; Lomas D.A.; Irving J.A.; Manno M.
materials (basel)issn: 1996-1944molecular diversity preservation international, 14, 2021
DOI: 10.3390/ma14102577

Osteosarcoma cell-derived exosomes affect tumor microenvironment by specific packaging of microRNAs
Raimondi, L., De Luca, A., Gallo, A., Costa, V., Russelli, G., Cuscino, N., Manno, M., Raccosta, S., Carina, V., Bellavia, D., Conigliaro, A., Alessandro, R., Fini, M., Conaldi, P.G., Giavaresi, G.
Carcinogenesis, 41, 2020
DOI: 10.1093/carcin/bgz130

Amyloid jams: Mechanical and dynamical properties of an amyloid fibrillar network
Martorana V, Raccosta S, Giacomazza D, Ditta LA, Noto R, Biagio PLS, Manno M
Biophysical chemistry, 253, 2019
DOI: 10.1016/j.bpc.2019.106231

Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis
Raimondo S, Saieva L, Vicario E, Pucci M, Toscani D, Manno M, Raccosta S, Giuliani N, Alessandro R
Journal of hematology & oncology, 12, 2019
DOI: 10.1186/s13045-018-0689-y

Palmitoylation is a post -translational modification of Alix regulating the membrane organization of exosome-like small extracellular vesicles
Romancino, Daniele P.; Buffa, Valentina; Caruso, Stefano; Ferrara, Ines; Raccosta, Samuele; Notaro, Antonietta; Campos, Yvan; Noto, Rosina; Martorana, Vincenzo; Cupane, Antonio; Giallongo, Agata; d'Azzo, Alessandra; Manno, Mauro; Bongiovanni, Antonella
biochimica et biophysica acta. g, general subjects (print), 1862, 2018
DOI: 10.1016/j.bbagen.2018.09.004

Interleukin 3-receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth
Bellavia D, Raimondo S, Calabrese G, Forte S, Cristaldi M, Patinella A, Memeo L, Manno M, Raccosta S, Diana P, Cirrincione G, Giavaresi G, Monteleone F, Fontana S, De Leo G, Alessandro R
Theranostics, 7, 2017
DOI: 10.7150/thno.17092

Embelin binds to human neuroserpin and impairs its polymerisation
Saga, Giorgia; Sessa, Fabio; Barbiroli, Alberto; Santambrogio, Carlo; Russo, Rosaria; Sala, Michela; Raccosta, Samuele; Martorana, Vincenzo; Caccia, Sonia; Noto, Rosina; Moriconi, Claudia; Miranda, Elena; Grandori, Rita; Manno, Mauro; Bolognesi, Martino;
Scientific reports , 6, 2016
DOI: 10.1038/srep18769

CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
Conigliaro A.; Costa V.; Lo Dico A.; Saieva L.; Buccheri S.; Dieli F.; Manno M.; Raccosta S.; Mancone C.; Tripodi M.; De Leo G.; Alessandro R.
Molecular cancer , 14, 2015
DOI: 10.1186/s12943-015-0426-x

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death
Raimondo S.; Naselli F.; Fontana S.; Monteleone F.; Lo Dico A.; Saieva L.; Zito G.; Flugy A.; Manno M.; Di Bella M.A.; De Leo G.; Alessandro R.
Oncotarget , 6, 2015
DOI: 10.18632/oncotarget.4004

Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: A possible role for exosomal disposal of miR-21
Taverna S.; Giallombardo M.; Pucci M.; Flugy A.; Manno M.; Raccosta S.; Rolfo C.; De Leo G.; Alessandro R.
Oncotarget , 6, 2015
DOI: 10.18632/oncotarget.4204

Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics
Noto, Rosina; Santangelo, Maria Grazia; Levantino, Matteo; Cupane, Antonio; Mangione, Maria Rosalia; Parisi, Daniele; Ricagno, Stéfano; Bolognesi, Martino; Manno, Mauro; Martorana, Vincenzo
Biochimica et biophysica acta. Proteins and proteomics , 1854, 2015
DOI: 10.1016/j.bbapap.2014.10.002

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum
Moriconi C, Ordoñez A, Lupo G, Gooptu B, Irving JA, Noto R, Martorana V, Manno M, Timpano V, Guadagno NA, Dalton L, Marciniak SJ, Lomas DA, Miranda E
The FEBS journal (online), 282, 2015
DOI: 10.1111/febs.13517

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation
Raimondi L.; De Luca A.; Amodio N.; Manno M.; Raccosta S.; Taverna S.; Bellavia D.; Naselli F.; Fontana S.; Schillaci O.; Giardino R.; Fini M.; Tassone P.; Santoro A.; De Leo G.; Giavaresi G.; Alessandro R.
Oncotarget , 6, 2015
DOI: 10.18632/oncotarget.3830

The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop
Noto R.; Randazzo L.; Raccosta S.; Caccia S.; Moriconi C.; Miranda E.; Martorana V.; Manno M.
Scientific reports , 5, 2015
DOI: 10.1038/srep13666

Protein-Protein Interactions in Dilute to Concentrated Solutions: alpha-Chymotrypsinogen in Acidic Conditions
Blanco, Marco A.; Perevozchikova, Tatiana; Martorana, Vincenzo; Manno, Mauro; Roberts, Christopher J.
Journal of physical chemistry b, 118, 2014
DOI: 10.1021/jp412301h

Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures
Nielsen SB, Macchi F, Raccosta S, Langkilde AE, Giehm L, Kyrsting A, Pii Svane AS, Manno M, Christiansen G, Nielsen NC, Oddershede L, Vestergaard B, Otzen DE
PloS one, 8, 2013
DOI: 10.1371/journal.pone.0067713

On the molecular structure of human neuroserpin polymers
Santangelo MG; Noto R; Levantino M; Cupane A; Ricagno S, Pezzullo M, Bolognesi M, Mangione MR, Martorana V, Manno M
Proteins, 80, 2012

The Tempered Polymerization of Human Neuroserpin
Noto R; Santangelo MG; Ricagno S; Mangione MR; Levantino M; Pezzullo M; Martorana V; Cupane A; Bolognesi M; Manno M
PloS one, 7, 2012
DOI: 10.1371/journal.pone.0032444

Thermodynamic versus Conformational Metastability in Fibril-Forming Lysozyme Solutions
Raccosta S; Martorana V; Manno M
Journal of physical chemistry b, 116, 2012

Existence of metastable intermediate lysozyme conformation highlights the role of alcohols in altering protein stability
D'Amico M, Raccosta S, Cannas M, Martorana V, Manno M
Journal of physical chemistry b, 115, 2011

Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress
Andersen CB, Manno M, Rischel C, Thórólfsson M, Martorana V
Protein science, 19, 2010

Amyloid gels: precocious appearance of elastic properties during the formation of an insulin fibrillar network
Manno M, Giacomazza D, Newman J, Martorana V, San Biagio PL
Langmuir, 26, 2010
DOI: 10.1021/la903340v

Irreversible gelation of thermally unfolded lysozyme: structural and mechanical properties of lysozyme aggregates
Raccosta S, Manno M, Bulone D, Giacomazza D, Militello V, Martorana V, San Biagio PL
European biophysics journal with biophysics letters, 39, 2010
DOI: 10.1007/s00249-009-0503-4

Two latent and two hyperstable polymeric froms of human neuroserpin
Ricagno S, Pezzullo M, Barbiroli A, Manno M, Levantino M, Santangelo MG, Bonomi F, Bolognesi M
Biophysical journal, 99, 2010

Protein stability modulated by a conformational effector: effects of trifluoroethanol on bovine serum albumin.
Carrotta R, Manno M, Giordano FM, Longo A, Portale G, Martorana V, Biagio PL
Physical chemistry chemical physics, 11, 2009
DOI: 10.1039/b818687a

A statistical light scattering approach to separating fast and slow dynamics.
Barthès J.; D. Bulone; M. Manno; V. Martorana; P. L. San Biagio.
European biophysics journal, 36, 2007
DOI: 10.1007/s00249-007-0163-1

Kinetics of different processes in human insulin amyloid formation.
Manno M.; Craparo E.F.; Podestà A.; Bulone D.; Carrotta R.; Martorana V.; Milani P.; Tiana G.; San Biagio P.L.
Journal of Molecular Biology, 366, 2007
DOI: 10.1016/j.jmb.2006.11.008

Large size fibrillar bundles of the alzheimer amyloid beta-protein.
Carrotta R.; J. Barthès; A. Longo; V. Martorana; M. Manno; G. Portale; P. L. San Biagio.
European biophysics journal, 36, 2007
DOI: 10.1007/s00249-007-0164-0

Early events in insulin fibrillization studied by time-lapse atomic force microscopy
Podestà A.; G.Tiana; P. Milani; M. Manno.
Biophysical journal, 90, 2006
DOI: 10.1529/biophysj.105.068833

Kinetics of insulin aggregation: disentanglement of amyloid fibrillation from large-size cluster formation.
Manno M.; Craparo E.F.; Martorana V.; Bulone D.; San Biagio P.L.
Biophysical journal, 90, 2006
DOI: 10.1529/biophysj.105.077636

Toxicity of recombinant beta-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus.
Carrotta R.; Di Carlo M.; Manno M.; Montana G.; Picone P.; Romancino D.; San Biagio P.L.
The FASEB journal, 20, 2006
DOI: 10.1096/fj.06-5716fje

Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.
Carrotta R.; Manno M.; Bulone D.; Martorana V.; San Biagio P.L.;
THE JOURNAL OF BIOLOGICAL CHEMISTRY (PRINT), 280, 2005
DOI: 10.1074/jbc.M500052200

Ergodic to non-ergodic transition monitored by scattered light intensity statistics
Manno, M; Bulone, D; Martorana, V; San Biagio, P L
PHYSICA. A, 341, 2004
DOI: 10.1016/j.physa.2004.04.107

The role of pH on instability and aggregation of sickle cell hemoglobin solutions.
Manno, M; San Biagio, Pl; Palma, Mu
PROTEINS (PRINT), 55, 2004
DOI: 10.1002/prot.10648

Thermodynamic instability and off-critical slowing down in supersaturated lysozyme solutions
Manno M. ; Bulone D. ; Martorana V. ; San Biagio P. L.
JOURNAL OF PHYSICS. CONDENSED MATTER (PRINT), 16, 2004
DOI: 10.1088/0953-8984/16/42/017