Eleonora Di Zanni
Master degree in Medical and Pharmaceutical Biotechnology, University of Genoa (2008);
PhD in Clinics, Genetics and Immunology of childhood diseases (2012);
Post-doc at in Laboratory of Molecular Genetics, Gaslini Institute, Genova (2012-2015);
Post-doc at Biophysics Institute (Cnr-Ibf) Genova (2015 – today)
orcid://0000-0003-4564-2202, ncbi://54215388
Research interests:
Key publications:
Di Zanni E, Gradogna A, Scholz-Starke J, Boccaccio A (2018) Gain of function of TMEM16E/ANO5 scrambling activity caused by a mutation associated with gnathodiaphyseal dysplasia. Cellular and Molecular Life Sciences 75:1657-1670. doi: 10.1007/s00018-017-2704-9
Di Zanni E, Bianchi G, Ravazzolo R, et al (2017) Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth. Oncotarget. 8:72133-72146. doi: 10.18632/oncotarget.19922
Carpaneto A, Boccaccio A, Lagostena L, Di Zanni E, Scholz-Starke J (2017) The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H+ exchange activity. EMBO Rep. 18:1100-1107. doi: 10.15252/embr.201643814
Bachetti T, Chiesa S, Castagnola P, Bani D, Di Zanni E, et al. (2013). Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). Ann Rheum Dis.72:1044-52. doi: 10.1136/annrheumdis-2012-201952
Di Zanni E, Bachetti T, Parodi S, et al. (2012) In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins. Neurobiol Dis. 45:508-18. doi: 10.1016/j.nbd.2011.09.007
Publications (6):
Phospholipid scrambling by a TMEM16 homolog of Arabidopsis thalianaBoccaccio, ANNA ELISABETTA; Picco, Cristiana; DI ZANNI, Eleonora; Joachim, Scholzstarke
THE FEBS JOURNAL (PRINT), 289, 2022
DOI: 10.1111/febs.16279
TMEM16E/ANO5 mutations related to bone dysplasia or muscular dystrophy cause opposite effects on lipid scrambling
Di Zanni, Eleonora; Gradogna, Antonella; Picco, Cristiana; Scholz-Starke, Joachim; Boccaccio, Anna
Human Mutation, 41, 2020
DOI: 10.1002/humu.24006
Lifting the veils on TMEM16E function
Boccaccio A, Di Zanni E, Gradogna A, Scholz-Starke J
Channels, 13, 2019
DOI: 10.1080/19336950.2018.1557470
Gain of function of TMEM16E/ANO5 scrambling activity caused by a mutation associated with gnathodiaphyseal dysplasia
Di Zanni E, Gradogna A, Scholz-Starke J, Boccaccio A
Cellular and molecular life sciences , 75, 2018
DOI: 10.1007/s00018-017-2704-9
Structural and functional differences in PHOX2B frameshift mutations underlie isolated or syndromic congenital central hypoventilation syndrome
Di Lascio, S; Benfante, R; Di Zanni, E; Cardani, S; Adamo, A; Fornasari, D; Ceccherini, I; Bachetti, T
HUMAN MUTATION, 39, 2018
DOI: 10.1002/humu.23365
The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H exchange activity.
Carpaneto A, Boccaccio A, Lagostena L, Di Zanni E, Scholz-Starke J
EMBO reports, 18, 2017
DOI: 10.15252/embr.201643814