Joachim Scholz - Starke

Research staff

Master degree in Biology, Friedrich-Alexander-University Erlangen-Nürnberg, Germany (1997)
PhD in Molecular Plant Physiology, Friedrich-Alexander-University Erlangen-Nürnberg (2002)
Post-doc positions at IBF-CNR and Istituto Italiano di Tecnologia (IIT), Genoa, Italy
Researcher (since 2011)
Senior Researcher (since 2021)

orcid://0000-0002-7376-6635, ncbi://56556896

Contact:

- Email joachim.scholzstarke@ibf.cnr.it
- Phone +39-010-6475593
- Location Genova

Website:

https://www.researchgate.net/profile/Joachim_Scholz-Starke

Research interests:

- Physiology and biophysics of plant vacuolar transport proteins (Principal investigator)
- Recordings of electronic currents from plant cytochromes
- Electronic transport mediated by proteins belonging to the cytochrome b561 family
- Study of the Ca2+-activated chloride channels and phospholipid scramblases of the TMEM16/Anoctamin family
- Functional activity of membrane channels and transporters by electrophysiology and fluorescence.

Further collaborations:

- Armando Carpaneto (DISTAV, University of Genoa, Italy)
- Kendal D. Hirschi (Children’s Nutrition Research Center, Baylor College of Medicine, Houston, USA)
- Roberto Gaxiola (School of Life Sciences, Arizona State University, Tempe, USA)
- Edgar Peiter (Institute of Agricultural and Nutritional Sciences, Martin-Luther University Halle-Wittenberg, Germany)

Key publications:

Carpaneto A, Boccaccio A, Lagostena L, Di Zanni E and Scholz-Starke J (2017) The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H+ exchange activity. EMBO Reports 18: 1100-1107

Meyer S, Scholz-Starke J, De Angeli A, Kovermann P, Burla B, Gambale F and Martinoia E (2011) Malate transport by the vacuolar AtALMT6 channel in guard cells is subject to multiple regulation. Plant Journal 67: 247-257

Scholz-Starke J, Primo Planta C, Yang J, Kandel R, Gaxiola RA and Hirschi KD (2019) The flip side of the Arabidopsis type I proton-pumping pyrophosphatase (AVP1): using a trans-membrane H+ gradient to synthesize pyrophosphate. Journal of Biological Chemistry 294: 1290-1299

Di Zanni E, Gradogna A, Scholz-Starke J and Boccaccio A (2018) Gain-of-function of TMEM16E/ANO5 scrambling activity caused by a mutation associated with gnathodiaphyseal dysplasia. Cellular and Molecular Life Sciences 71: 4275-4283

Picco C, Scholz-Starke J, Festa M, Costa A, Sparla F, Trost P and Carpaneto A (2015) Direct Recording of Trans-Plasma Membrane Electron Currents Mediated by a Member of the Cytochrome b561 Family of Soybean. Plant Physiology 169: 986-995

Publications (27):

Ferric reduction by a CYBDOM protein counteracts increased iron availability in root meristems induced by phosphorus deficiency
Maniero, Rodolfo A.; Picco, Cristiana; Hartmann, Anja; Engelberger, Felipe; Gradogna, Antonella; Scholz-Starke, Joachim; Melzer, Michael; Künze, Georg; Carpaneto, Armando; von Wirén, Nicolaus; Giehl, Ricardo F. H.
NATURE COMMUNICATIONS, 15, 2024
DOI: 10.1038/s41467-023-43912-w

Beyond the patch-clamp resolution:functional activity of non-electrogenic vacuolar NHX proton/potassium antiporters and inhibition by phosphoinositides
Antonella Gradogna, Joachim Scholz-Starke, José M Pardo, Armando Carpaneto
New Phytologist, 2020
DOI: 10.1111/nph.17021

TMEM16E/ANO5 mutations related to bone dysplasia or muscular dystrophy cause opposite effects on lipid scrambling
Di Zanni, Eleonora; Gradogna, Antonella; Picco, Cristiana; Scholz-Starke, Joachim; Boccaccio, Anna
Human Mutation, 41, 2020
DOI: 10.1002/humu.24006

Lifting the veils on TMEM16E function
Boccaccio A, Di Zanni E, Gradogna A, Scholz-Starke J
Channels, 13, 2019
DOI: 10.1080/19336950.2018.1557470

Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength
Rocchi A, Moretti D, Lignani G, Colombo E, Scholz-Starke J, Baldelli P, Tkatch T, Benfenati F
Molecular neurobiology, 56, 2019
DOI: 10.1007/s12035-019-1492-7

Plant proton pumping pyrophosphatase: the potential for its pyrophosphate synthesis activity to modulate plant growth
Primo C, Pizzio GA, Yang J, Gaxiola RA, Scholz-Starke J, Hirschi KD
Plant biology, 21, 2019
DOI: 10.1111/plb.13007

The flip side of the Arabidopsis type I proton-pumping pyrophosphatase (AVP1): Using a transmembrane H+ gradient to synthesize pyrophosphate
Scholz-Starke J, Primo C, Yang J, Kandel R, Gaxiola RA, Hirschi KD
The Journal of biological chemistry, 294, 2019
DOI: 10.1074/jbc.RA118.006315

Gain of function of TMEM16E/ANO5 scrambling activity caused by a mutation associated with gnathodiaphyseal dysplasia
Di Zanni E, Gradogna A, Scholz-Starke J, Boccaccio A
Cellular and molecular life sciences , 75, 2018
DOI: 10.1007/s00018-017-2704-9

Understanding the Molecular Basis of Salt Sequestration in Epidermal Bladder Cells of Chenopodium quinoa
Böhm J, Messerer M, Müller HM, Scholz-Starke J, Gradogna A, Scherzer S, Maierhofer T, Bazihizina N, Zhang H, Stigloher C, Ache P, Al-Rasheid KAS, Mayer KFX, Shabala S, Carpaneto A, Haberer G, Zhu JK, Hedrich R
Current biology, 28, 2018
DOI: 10.1016/j.cub.2018.08.004

Electron current recordings in living cells
Trost P, Picco C, Scholz-Starke J, Festa M, Lagostena L, Costa A, Sparla F, Carpaneto A
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.05.006

How may PI(3,5)P2 impact on vacuolar acidification?
Scholz-Starke J.
Channels, 2017
DOI: 10.1080/19336950.2017.1354584

The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H exchange activity.
Carpaneto A, Boccaccio A, Lagostena L, Di Zanni E, Scholz-Starke J
EMBO reports, 18, 2017
DOI: 10.15252/embr.201643814

Stepping Out of the Shade: Control of Neuronal Activity by the Scaffold Protein Kidins220/ARMS.
Scholz-Starke, Joachim; Cesca, Fabrizia
Frontiers in cellular neuroscience, 10, 2016
DOI: 10.3389/fncel.2016.00068

Direct Recording of Trans-Plasma Membrane Electron Currents Mediated by a Member of the Cytochrome b561 Family of Soybean.
Picco, Cristiana; Scholz-Starke, Joachim; Festa, Margherita; Costa, Alex; Sparla, Francesca; Trost, Paolo; Carpaneto, Armando
Plant physiology , 169, 2015
DOI: 10.1104/pp.15.00642

Functional Interaction between the Scaffold Protein Kidins220/ARMS and Neuronal Voltage-Gated Na+ Channels.
Cesca, Fabrizia; Satapathy, Annyesha; Ferrea, Enrico; Nieus, Thierry; Benfenati, Fabio; Scholz-Starke, Joachim
Journal of biological chemistry (online), 290, 2015
DOI: 10.1074/jbc.M115.654699

Identification of mutations allowing Natural Resistance Associated Macrophage Proteins (NRAMP) to discriminate against cadmium
Pottier, Mathieu; Oomen, Ronald; Picco, Cristiana; Giraudat, Jerome; Scholz-Starke, Joachim; Richaud, Pierre; Carpaneto, Armando; Thomine, Sebastien
Plant journal , 83, 2015
DOI: 10.1111/tpj.12914

How Are Cytochrome b561 Electron Currents Controlled by Membrane Voltage and Substrate Availability?
Picco, Cristiana; Scholz-Starke, Joachim; Naso, Alessia; Preger, Valeria; Sparla, Francesca; Trost, Paolo; Carpaneto, Armando
Antioxidants & redox signalling, 21, 2014
DOI: 10.1089/ars.2013.5809

The phosphoinositide PI(3,5)P-2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells
Boccaccio, Anna; Scholz-Starke, Joachim; Hamamoto, Shin; Larisch, Nina; Festa, Margherita; Gutla, Paul Vijay Kanth; Costa, Alex; Dietrich, Petra; Uozumi, Nobuyuki; Carpaneto, Armando
Cellular and molecular life sciences , 71, 2014
DOI: 10.1007/s00018-014-1623-2

The putative K+ channel subunit AtKCO3 forms stable dimers in Arabidopsis
Rocchetti A., Sharma T., Wulfetange C., Scholz-Starke J., Grippa A., Carpaneto A., Dreyer I., Vitale A., Czempinski K., Pedrazzini E.
Frontiers in plant science , 3, 2014
DOI: 10.3389/fpls.2012.00251

Kidins220/ARMS Is a Novel Modulator of Short-Term Synaptic Plasticity in Hippocampal GABAergic Neurons
Scholz-Starke J; Cesca F; Schiavo G; Benfenati F; Baldelli P
PloS one, 7, 2012

Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems
Cesca F; Yabe A; Spencer-Dene B; Scholz-Starke J; Medrihan L; Maden CH; Gerhardt H; Orriss IR; Baldelli P; Al-Qatari M; Koltzenburg M; Adams RH; Benfenati F; Schiavo G
Cell death and differentiation, 19, 2012

The Arabidopsis central vacuole as an expression system for intracellular transporters: functional characterization of the Cl-/H+ exchanger CLC-7
Costa A; Gutla PVK; Boccaccio A; Scholz-Starke J; Festa M; Basso B; Zanardi I; Pusch M; Lo Schiavo F; Gambale F; Carpaneto A
Journal of physiology, 590, 2012
DOI: 10.1113/jphysiol.2012.230227

Malate transport by the vacuolar AtALMT6 channel in guard cells is subject to multiple regulation
Meyer S, Scholz-Starke J, De Angeli A, Kovermann P, Burla B, Gambale F, Martinoia E
Plant journal, 67, 2011

Fluorescence. Combined with excised patch: measuring calcium currents in plant cation channels.
Gradogna A, Scholz-Starke J, Gutla PV, Carpaneto A
Plant journal, 58, 2009
DOI: 10.1111/j.1365-313X.2008.03762.x

Response to cytosolic nickel of Slow Vacuolar channels in the hyperaccumulator plant Alyssum bertolonii.
Corem S, Carpaneto A, Soliani P, Cornara L, Gambale F, Scholz-Starke J
European biophysics journal with biophysics letters, 38, 2009

The Arabidopsis vacuolar malate channel is a member of the ALMT family
Kovermann P; Meyer S; Hörtensteiner S; Picco C; Scholz-Starke J; Ravera S; Lee Y; Martinoia E
Plant journal, 52, 2007
DOI: 10.1111/j.1365-313X.2007.03367.x

On the interaction of neomycin with the Slow Vacuolar channel of Arabidopsis thaliana
Scholz-Starke J, Carpaneto A, Gambale F
Journal of general physiology, 127, 2006
DOI: 10.1085/jpg.200509402