Personal Card



Silvia Vilasi

Research staff

Contact:

- Email silvia.vilasi@ibf.cnr.it
- Phone +39-091-6809338
- Location Palermo

Research interests:

- Extraction and characterization of polyphenols from complex systems of agri-food origin; study of antioxidant properties and of neuroprotective and anti-amyloidogenic effects in neurodegenerative processes
- Amyloid aggregation processes and their inhibition
- Model Membrane Systems and Interaction Studies
- Structure and Functionality of Molecular chaperones

Publications (20):

FLIM-Phasor Analysis (FLIM-ϕ) of Aβ-Induced Membrane Order Alterations: Towards a Cell-Based Biosensor for Early Alzheimer’s Disease Diagnosis
Battisti, Antonella; Grazia Ortore, Maria; Vilasi, Silvia; Sgarbossa, Antonella
MICROMACHINES, 16, 2025
DOI: 10.3390/mi16020234

Moringa oleifera Extracts as Strategic Phyto‐Therapy for Alzheimer's Disease
Carrotta, Rita; Vilasi, Silvia; Costa, Maria Assunta; Librizzi, Fabio; Martorana, Vincenzo; Passantino, Rosa; Buzzanca, Carla; di Stefano, Vita; Ortore, Maria Grazia; Piccirillo, Silvia; Preziuso, Alessandra; Magi, Simona; Mangione, Maria Rosalia
FOOD SCIENCE & NUTRITION, 13, 2025
DOI: 10.1002/fsn3.70007

Studying an orphan disease by a biophysical approach: The case of cblC
Vilasi, S.; Longo, L.; Randazzo, L.; Bollati, M.; Carrotta, R.; Costa, M. A.; De Rosa, M.; Mangione, M. R.; Martorana, V.; Milani, M.; Ortore, M. G.; Tutone, M.; Passantino, R.
IL NUOVO CIMENTO C, 47, 2024
DOI: 10.1393/ncc/i2024-24318-2

The Possible Role of the Type I Chaperonins in Human Insulin Self-Association
Pizzo, Federica; Mangione, MARIA ROSALIA; Librizzi, Fabio; Manno, Mauro; Martorana, Vincenzo; Noto, Rosina; Vilasi, Silvia
LIFE, 12, 2022
DOI: 10.3390/life12030448

Valorization of apple peels through the study of the effects on the amyloid aggregation process of ?-casein
Guarrasi V., Rappa G.C., Costa M.A., Librizzi F., Raimondo M., Di Stefano V., Germanà M.A., Vilasi S.
molecules (basel, online)issn: 1420-3049molecules/mdpi, molecular diversity preservation international, 26, 2021
DOI: 10.3390/molecules26082371

Hydroxytyrosol Inhibits Protein Oligomerization and Amyloid Aggregation in Human Insulin
Sirangelo, Ivana; Borriello, Margherita; Vilasi, Silvia; Iannuzzi, Clara
International Journal Of Molecular Sciences, 21, 2020
DOI: 10.3390/ijms21134636

Amyloid beta-Peptide Interaction with Membranes: Can Chaperones Change the Fate?
Ricci C, Maccarini M, Falus P, Librizzi F, Mangione MR, Moran O, Ortore MG, Schweins R, Vilasi S, Carrotta R
Journal of physical chemistry b, 123, 2019
DOI: 10.1021/acs.jpcb.8b11719

Inhibition of AB1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL
Vilasi S, Carrotta R, Ricci C, Rappa GC, Librizzi F, Martorana V, Ortore MG, Mangione MR
ACS chemical neuroscience, 10, 2019
DOI: 10.1021/acschemneuro.9b00183

Chaperonin of Group I: Oligomeric spectrum and biochemical and biological implications
Vilasi S, Bulone D, Caruso Bavisotto C, Campanella C, Marino Gammazza A, San Biagio PL, Cappello F, Conway de Macario E, Macario AJL
Frontiers in Molecular Biosciences, 4, 2018
DOI: 10.3389/fmolb.2017.00099

Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti A, Palumbo Piccionello A, Sgarbossa A, Vilasi S, Ricci C, Ghetti F, Spinozzi F, Marino Gammazza A, Giacalone V, Martorana A, Lauria A, Ferrero C, Bulone D, Mangione MR, San Biagio PL, Ortore MG
RSC advances, 7, 2017
DOI: 10.1039/c7ra05300b

Investigation Investigation on different chemical stability of mitochondrial Hsp60 and its precursor
Ricci C, Carrotta R, Rappa GC, Mangione MR, Librizzi F, San Biagio PL, Amenitsch H, Ortore MG, Vilasi S
Biophysical chemistry , 229, 2017
DOI: 10.1016/j.bpc.2017.07.008

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
Pasquale Picone, Silvia Vilasi, Fabio Librizzi, Marco Contardi, Domenico Nuzzo, Luca Caruana, Sara Baldassano, Antonella Amato, Flavia Mulè, Pier Luigi San Biagio, Daniela Giacomazza, Marta Di Carlo
Aging , 8, 2016
DOI: 10.18632/aging.101004

Hsp60, amateur chaperone in amyloid-beta fibrillogenesis
Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL
Biochimica et biophysica acta. G, General subjects, 1860, 2016
DOI: 10.1016/j.bbagen.2016.07.019

Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins
Ricci, Caterina; Ortore, Maria Grazia; Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Bulone, Donatella; Librizzi, Fabio; Spinozzi, Francesco; Burgio, Giosalba; Amenitsch, Heinz; San Biagio, Pier Luigi
Biophysical chemistry, 208, 2016
DOI: 10.1016/j.bpc.2015.07.006

Photo-inhibition of A beta fibrillation mediated by a newly designed fluorinated oxadiazole
Mangione, M. R.; Piccionello, A. Palumbo; Marino, C.; Ortore, M. G.; Picone, P.; Vilasi, S.; Di Carlo, M.; Buscemi, S.; Bulone, D.; Biagio, P. L. San
RSC advances , 5, 2015
DOI: 10.1039/c4ra13556c

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Vilasi, Silvia; Carrotta, Rita; Mangione, Maria Rosalia; Campanella, Claudia; Librizzi, Fabio; Randazzo, Loredana; Martorana, Vincenzo; Gammazza, Antonella Marino; Ortore, Maria Grazia; Vilasi, Annalisa; Pocsfalvi, Gabriella; Burgio, Giosalba; Corona, Dav
PloS one, 9, 2014
DOI: 10.1371/journal.pone.0097657

Unraveling amyloid toxicity pathway in NIH3T3 cells by a combined proteomic and 1H-NMR metabonomic approach
Vilasi A; Vilasi S; Romano R; Acernese F; Barone F; Balestrieri ML; Maritato R; Irace G; Sirangelo I
Journal of cellular physiology, 228, 2013

alpha-Casein Inhibition Mechanism in Concanavalin A Aggregation Process
Carrotta R; Vilasi S; Librizzi F; Martorana V; Bulone D; San Biagio PL
Journal of physical chemistry b, 116, 2012
DOI: 10.1021/jp307417x

Entrapment of A Beta 1-40 peptide in unstructured aggregates
Corsale C; Carrotta R; Mangione MR; Vilasi S; Provenzano A; Cavallaro G; Bulone D; San Biagio PL
Journal of physics. Condensed matter, 24, 2012
DOI: 10.1088/0953-8984/24/24/244103

Resolution of the effects induced by W->F substitutions on the conformation and dynamics of the amyloid-forming apomyoglobin mutant W7FW14F
Infusini G; Iannuzzi C; Vilasi S; Birolo L; Pagnozzi D; Pucci P; Irace G; Sirangelo I
European biophysics journal, 41, 2012