Debora Baroni

Research staff

In 2001 I got my degree in Biology and in 2005 a PhD in Pharmacology and Clinical Toxicology at the University of Genoa. My research activities consists in in vitro and in vivo toxicity and carcinogenicity studies and in in vitro studies on the pharmacological activity of compounds of new synthesis. I am leading also studies aimed to the functional and biochmical characterization of the mutations of the voltage-gated sodium channel subunits related to hereditary channelopathies and to define the structural and functional features of wild type and mutant CFTR proteins. In particular I am getting involved in the evaluation of the pharmacological effects of new CFTR modulators.

orcid://0000-0001-8764-2468, ncbi://56481858

Contact:

- Email debora.baroni@ibf.cnr.it
- Phone +39-010-6475559
- Location Genova

Research interests:

- Molecular pharmacology of cystic fibrosis
- Genetic diseases caused by mutations of the auxiliary subunits of the sodium channel

Financial support:

- Dissecting the rescue mechanisms mediated by CFTR correctors. Progetto 3#2018, Fondazione per la ricerca sulla fibrosi Cistica

Key publications:

GianottiA, Capurro V, Delpiano L, Mielczarek M, García-ValverdeM, Carreira-BarralI, Ludovico A, Fiore M, Baroni D, Moran O, Quesada R, Caci E (2020). Small molecule anion carriers correct abnormal airway surface liquid properties in cystic fibrosis airway epithelia. Accepted by Int J Mol Sci

Amico G, Brandas C, Moran O, Baroni D. (2019). Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors. Int J Mol Sci. Nov1;20(21).

Baroni D, Picco C, Moran O. (2018). “A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel”. Hum Mutat. 39:1402-1415.

L. Corso, A. Cavallero, D. Baroni, P. Garbati, G. Prestipino, S. Bisti, M. Nobile, C. Picco. (2016). “Saffron reduces ATP-induced retinal cytotoxicity by targeting P2X7 receptors”. Purinergic Signal. 12:161-74

D. Baroni, O. Zegarra-Moran, O. Moran. (2015). “Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS”. Cell. Mol. Life Sci. 72: 1363-1375

Publications (19):

Elexacaftor Mediates the Rescue of F508del CFTR Functional Expression Interacting with MSD2
Bongiorno, Roberta; Ludovico, Alessandra; Moran, Oscar; Baroni, Debora
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 2023
DOI: 10.3390/ijms241612838

Modulator Combination Improves In Vitro the Microrheological Properties of the Airway Surface Liquid of Cystic Fibrosis Airway Epithelia
Ludovico, Alessandra; Oscar, Moran; Baroni, Debora
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (ONLINE), 23, 2022
DOI: 10.3390/ijms231911396

Nbd2 is required for the rescue of mutant f508del cftr by a thiazole-based molecule: A class ii corrector for the multi-drug therapy of cystic fibrosis
Brandas C.; Ludovico A.; Parodi A.; Moran O.; Millo E.; Cichero E.; Baroni D.
biomolecules, 11, 2021
DOI: 10.3390/biom11101417

Computational Design of Nucleic Acid-Based Bioreceptor for Contaminants of Emerging Concern
Arrigo, Patrizio; Baroni, Debora
Sensors In Water Pollutants Monitoring: Role Of Material, 2020
DOI: 10.1007/978-981-15-0671-0_12

Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
Gianotti, Ambra; Capurro, Valeria; Delpiano, Livia; Mielczarek, Marcin; Garcia-Valverde, Maria; Carreira-Barral, Israel; Ludovico, Alessandra; Fiore, Michele; Baroni, Debora; Moran, Oscar; Quesada, Roberto; Caci, Emanuela
International Journal Of Molecular Sciences, 21, 2020
DOI: 10.3390/ijms21041488

Lumacaftor-rescued F508del-CFTR has a modified bicarbonate permeability
Ferrera L, Baroni D, Moran O
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18, 2019
DOI: 10.1016/j.jcf.2019.01.012

Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
Fiore M, Cossu C, Capurro V, Picco C, Ludovico A, Mielczarek M, Carreira-Barral I, Caci E, Baroni D, Quesada R, Moran O
British journal of pharmacology, 176, 2019
DOI: 10.1111/bph.14649

Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors
Amico G, Brandas C, Moran O, Baroni D
International journal of molecular sciences, 20, 2019
DOI: 10.3390/ijms20215463

A mutation of SCN1B associated with GEFS+ causes functional and maturation defects of the voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Human mutation, 39, 2018
DOI: 10.1002/humu.23589

Anion-transport mechanism of a triazole-bearing derivative of prodigiosine: A candidate for cystic fibrosis therapy
Cossu C, Fiore M, Baroni D, Capurro V, Caci E, Garcia-Valverde M, Quesada R, Moran O
Frontiers in Pharmacology, 9, 2018
DOI: 10.3389/fphar.2018.00852

Mutation E87Q of the beta 1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel
Baroni D, Picco C, Moran O
Scientific reports , 7, 2017
DOI: 10.1038/s41598-017-10645-y

Saffron reduces ATP-induced retinal cytotoxicity by targeting P2X7 receptors
Corso, Lucia; Cavallero, Anna; Baroni, Debora; Garbati, Patrizia; Prestipino, Gianfranco; Bisti, Silvia; Nobile, Mario; Picco, Cristiana
Purinergic signalling, 12, 2016
DOI: 10.1007/s11302-015-9490-3

Differential gene expression profiles of two excitable rat cell lines after over-expression of WT- and C121W-?1 sodium channel subunits
Baroni, D.; Moran, O.
Neuroscience , 297, 2015
DOI: 10.1016/j.neuroscience.2015.03.052

Functional and pharmacological induced structural changes of the cystic fibrosis transmembrane conductance regulator in the membrane solved using SAXS
Baroni, Debora; Zegarra-Moran, Olga; Moran, Oscar
Cellular and molecular life sciences , 72, 2015
DOI: 10.1007/s00018-014-1747-4

On the multiple roles of the voltage gated sodium channel beta1 subunit in genetic diseases.
Baroni, Debora; Moran, Oscar
Frontiers in Pharmacology , 6, 2015
DOI: 10.3389/fphar.2015.00108

Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression
Baroni, Debora; Picco, Cristiana; Barbieri, Raffaella; Moran, Oscar
Biology of the cell, 106, 2014
DOI: 10.1111/boc.201300040

Direct interaction of a cftr potentiator and a cftr corrector with phospholipid bilayers
Baroni D.; Zegarra-Moran O.; Svensson A.; Moran O.
European biophysics journal, 43, 2014
DOI: 10.1007/s00249-014-0956-y

Identification of an intra-molecular disulfide bond in the sodium channel beta 1-subunit
Barbieri R; Baroni D; Moran O
Biochemical and biophysical research communications, 420, 2012

Molecular differential expression of voltage-gated sodium channel alpha and beta subunit mRNAs in five different mammalian cell lines
Baroni D, Moran O
Journal of bioenergetics and biomembranes, 43, 2011